黄芩苷
纳米颗粒
化学
细胞生长
细胞生物学
纳米技术
癌症研究
材料科学
医学
生物化学
生物
高效液相色谱法
色谱法
作者
Zhenghan Liu,Yadong Chen,Weimin Zeng,Yang Liu,Dandan Zhao,Yanlong Zhang,Xiangqian Jia
标识
DOI:10.1016/j.jddst.2024.105757
摘要
Materpaials-based drug delivery systems can enhance the effect of cancer treatment by improving chemotherapy and immunomodulation. Recent research revealed that Baicalin(BA)have good immunomodulatory activity and anti-tumor effect. Here, a pH-sensitive tumor-targeting delivery system for Baicalin (BA-LP-PEOz) was constructed using DSPE-PEOz for pH sensitization. This preparation method was conducted using three single-factor experiments. Response surface Box-Behnken (BBD) design was used to optimize the factor levels. Our results showed that BA-LP-PEOz had synergistic capacity of inhibiting tumor cell (HepG2,4T1 and A549) growth and activating macrophages (RAW264.7). Further mechanistic studies revealed that BA-LP-PEOz can activate RAW264.7 by affecting the NF-κB signaling pathway. We expect that the improved efficacy of the synergetic system provides a prospective strategy for cancer therapy.
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