纳米团簇
生物膜
光热治疗
体内
化学
胞外聚合物
微生物学
纳米技术
材料科学
生物
细菌
有机化学
遗传学
生物技术
作者
Youhuan Gong,Xueying Zhao,Xiaojie Yan,Wenfu Zheng,Huanwen Chen,Le Wang
标识
DOI:10.1016/j.jcis.2024.06.172
摘要
The biofilm-mediated implant infections pose a huge threat to human health. It is urgent to explore strategies to combat biofilm-mediated infections. Herein, we design 3-amino-1,2,4-triazole-5-thiol (ATT)-modified gold nanoclusters (AGNCs) to realize biofilm-targeting and near-infrared (NIR)-II light-responsive antibiofilm therapy. The AGNCs can interact with the bacterial extracellular DNA through the formation of hydrogen bonds between the amine groups on the ATT and the hydroxyl groups on the DNA. The AGNCs demonstrate photothermal properties even at a low power density (0.5 W/cm2) for a short-time (5 min) irradiation, making them highly effective in eradicating the biofilm with a dispersion rate up to 90 %. In vivo infected catheter implantation model demonstrates an exceptional high ability of the AGNCs to eradicate approximately 90 % of the bacteria encased within the biofilms. Moreover, the AGNCs show no detectable toxicity or systemic effects in mice. Our study suggests the great potential of the AGNCs for long-term prevention and elimination of the biofilm-mediated infections.
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