A comprehensive study of Tianma Toutong Tablets from the dual dimensions of quality and efficacy using fingerprint techniques and network pharmacology.

化学 指纹(计算) 对偶(语法数字) 传统医学 药理学 人工智能 医学 艺术 文学类 计算机科学
作者
Siqi Wang,Ziyu Yang,Manhuayun Zhai,Ping Guo,Guoxiang Sun
出处
期刊:Analytica Chimica Acta [Elsevier]
卷期号:1318: 342928-342928
标识
DOI:10.1016/j.aca.2024.342928
摘要

The quality of traditional Chinese medicine (TCM) is the prerequisite for ensuring its safe and effective clinical application. With the increasing popularity of TCM worldwide, the quality control of TCM products has become increasingly crucial. Tianma toutong tablet (TMTTT) is mainly used for migraine caused by external wind and cold, blood stasis, or deficiency of blood and nourishment. However, the mechanism of action of TMTTT is still unclear, and there has been a lack of in vitro antioxidant activity research and migraine treatment mechanism research. Therefore, it is urgent to establish a set of comprehensive and effective evaluation methods. three fingerprint profiles were established using HPLC, UV, and DSC analysis methods, and established three digital parameters simple complexity index (SX), simple clarity index (SY), simple complexity clarity ratio (Sω), 22 batches of samples were evaluated using a comprehensive linear quantitative fingerprint method (CLQFM). In addition, the antioxidant activity of the samples was determined using the DPPH method, and the relationship between fingerprint peaks in different fingerprints and antioxidant capacity was explored using Pearson correlation coefficients. Finally, network pharmacological research was conducted to investigate the potential targets, compounds, and pathways involved in the treatment of migraines with TMTTT. The results showed that the 22 batches of samples were classified into different quality grades. TMTTT exhibited good antioxidant activity, the fingerprint-efficacy relationship showed that gastrodin, chlorogenic acid, ferulic acid, imperatorin and isoimperatorin had strong antioxidant capacity, providing directions for the identification of active compounds. A total of 36 core targets were identified and screened by network pharmacology, which AKT serine/threonine kinase 1 (AKT1), albumin (ALB), insulin (INS), tumor necrosis factor (TNF), prostaglandin-endoperoxide synthase 2 (PTGS2) and interleukin-6 (IL-6), and compounds such as β-sitosterol, chrysophanol, vanillin are the key to the treatment of migraine, providing references for subsequent clinical research and new drug development. Significance: This study examined the consistency of the quality of TMTTT and the mechanism of action in treating migraines from both quality and efficacy perspectives, providing a favorable direction for further research on TMTTT and offering new ideas for the quality control of TCM compound formulations.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
zhlh完成签到,获得积分10
刚刚
深情安青应助科研通管家采纳,获得10
刚刚
隐形曼青应助北欧海盗采纳,获得10
刚刚
CipherSage应助科研通管家采纳,获得10
1秒前
CipherSage应助科研通管家采纳,获得10
1秒前
浆果肉丸应助liu采纳,获得10
1秒前
华仔应助科研通管家采纳,获得10
1秒前
Kyo应助科研通管家采纳,获得10
1秒前
1秒前
cctv18应助执着以山采纳,获得10
1秒前
1秒前
2秒前
英俊的铭应助要减肥冰菱采纳,获得10
2秒前
2秒前
无花果应助科研通管家采纳,获得10
2秒前
9527完成签到,获得积分10
3秒前
3秒前
3秒前
C17发布了新的文献求助10
4秒前
9527发布了新的文献求助10
5秒前
5秒前
刻苦的鸭子完成签到 ,获得积分10
5秒前
6秒前
7秒前
MsEEi发布了新的文献求助10
9秒前
Pauline完成签到 ,获得积分10
10秒前
柳代云完成签到,获得积分10
10秒前
毛豆应助斯文泥猴桃采纳,获得10
11秒前
13秒前
Jim luo发布了新的文献求助10
14秒前
深情安青应助花佩剑采纳,获得10
15秒前
Sammy完成签到,获得积分10
16秒前
懒咩咩完成签到,获得积分10
17秒前
元气蛋完成签到,获得积分10
18秒前
18秒前
腼腆的烤鸡完成签到,获得积分10
19秒前
橘子完成签到,获得积分10
20秒前
香蕉觅云应助C17采纳,获得10
21秒前
21秒前
穆紫应助hkh采纳,获得10
21秒前
高分求助中
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
草地生态学 880
Threaded Harmony: A Sustainable Approach to Fashion 799
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
"Sixth plenary session of the Eighth Central Committee of the Communist Party of China" 400
Introduction to Modern Controls, with illustrations in MATLAB and Python 310
PROJECT STUDIES; -A LATE MODERN UNIVERSITY REFORM? 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3057772
求助须知:如何正确求助?哪些是违规求助? 2714072
关于积分的说明 7439066
捐赠科研通 2359232
什么是DOI,文献DOI怎么找? 1249940
科研通“疑难数据库(出版商)”最低求助积分说明 607315
版权声明 596334