TLR3型
封锁
气道
信号转导
细胞生物学
免疫学
医学
Toll样受体
生物
先天免疫系统
受体
内科学
免疫系统
麻醉
作者
Gunnar Pejler,Ella Fagerström,Ella Fagerström,Aida Paivandy
标识
DOI:10.1016/j.jaci.2024.05.031
摘要
Endolysosomal compartments are acidic and contain low pH-dependent proteases, and these conditions are exploited by respiratory viruses, such as SARS-CoV-2 and influenza virus, for escaping into the cytosol. Moreover, endolysosomes contain various pattern recognition receptors (PRRs), which respond to virus-derived pathogen-associated molecular patterns (PAMPs) by production of pro-inflammatory cytokines/chemokines. However, excessive pro-inflammatory responses can lead to a potentially lethal cytokine storm.
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