正交性
纳米技术
脚手架
组织工程
生物分子
灵活性(工程)
膜
表面改性
纳米材料
材料科学
表面工程
DNA
化学
工程类
生物医学工程
生物化学
统计
几何学
数学
物理化学
作者
Wei Li,Shuyun Liu,Zhenghao Wang,Liping Gou,Yiran Ou,Xinyue Zhu,Ye Zhou,Tianci Zhang,Jiaye Liu,Xiaoliang Zheng,Per-Olof Berggren,Jingping Liu,Xiaofeng Zheng
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-06-10
卷期号:24 (24): 7548-7556
标识
DOI:10.1021/acs.nanolett.4c02193
摘要
Cell membrane-based nanovesicles (CMNVs) play pivotal roles in biomolecular transportation in living organisms and appear as attractive bioinformed nanomaterials for theranostic applications. However, the current surface-engineering technologies are limited in flexibility and orthogonality, making it challenging to simultaneously display multiple different ligands on the CMNV surface in a precisely controlled manner. Here, we developed a DNA scaffold-programmed approach to orthogonally engineer CMNVs with versatile ligands. The designed DNA scaffolds can rapidly anchor onto the CMNV surface, and their unique sequences and hybridized properties enable independent control of the loading of multiple different types of biomolecules on the CMNVs. As a result, the orthogonal engineering of CMNVs with a renal targeted peptide and a therapeutic protein at controlled ratios demonstrated an enhanced renal targeting and repair potential
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