细胞毒性T细胞
癌症干细胞
生物
癌细胞
癌症研究
干细胞
癌症
体外
化学
细胞生物学
生物化学
遗传学
作者
Dong Yang,Zhi Dai,Peifen Zhu,Wang Gan,Bin Sun,Shirong Li,Junjun Hao,Yifen Wang,Yaping Liu,Shuaishuai Yu,Ren Lai,Xiao‐Dong Luo,Xudong Zhao
出处
期刊:Phytomedicine
[Elsevier BV]
日期:2022-10-06
卷期号:108: 154492-154492
被引量:6
标识
DOI:10.1016/j.phymed.2022.154492
摘要
Our study yielded an effective approach to screen for CSC-specific agents. Through this approach, we identified taccaoside A from the rhizomatous geophyte Tacca. subflabellata are cytotoxic to CSCs through a molecular mechanism that involves RAS binding and suppression of its downstream signaling. Our findings indicate taccaoside A is a potential lead compound for anti-CSC drug discovery.
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