神经调节
前额叶皮质
萧条(经济学)
神经科学
心理学
病变
磁刺激
扁桃形结构
颞叶
经颅直流电刺激
医学
刺激
精神科
认知
经济
癫痫
宏观经济学
作者
Shan H. Siddiqi,Noah S. Philip,Stephan Palm,David Carreon,Amanda R. Arulpragasam,Jennifer Barredo,Heather C. Bouchard,Jordan Grafman,Jordan Grafman,Rajendra A. Morey,Michael Fox
出处
期刊:Research Square - Research Square
日期:2024-03-19
被引量:1
标识
DOI:10.21203/rs.3.rs-3132332/v1
摘要
Abstract Neuromodulation trials for PTSD have yielded mixed results, and the optimal neuroanatomical target remains unclear. We analyzed three datasets to study brain circuitry causally linked to PTSD in military Veterans. After penetrating traumatic brain injury (n=193), lesions that reduced probability of PTSD were preferentially connected to a circuit including the medial prefrontal cortex (mPFC), amygdala, and anterolateral temporal lobe (cross-validation p=0.01). In Veterans without lesions (n=180), PTSD was specifically associated with connectivity within this circuit (p<0.01). Connectivity change within this circuit correlated with PTSD improvement after transcranial magnetic stimulation (TMS) (n=20) (p<0.01), even though the circuit was not directly targeted. Finally, we directly targeted this circuit with fMRI-guided accelerated TMS, leading to rapid resolution of symptoms in a patient with severe lifelong PTSD. All results were independent of depression severity. This lesion-based PTSD circuit may serve as a neuromodulation target for Veterans with PTSD.
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