Abstract: In recent years, graphene oxides have convoked significant attention across various scientific disciplines, including physics, chemistry, and materials science, owing to their extraordinary physical properties, chemical tunability, and vast possibilities for their applications. As a result, our keen interest lies in exploring nanographene oxide and presenting a comprehensive review on this subject. This paper provides a thorough examination of eminently progressive advancements in the synthesis, properties, and performance of graphene oxide. Synthetic chemists venturing into this expanding field of material science and researchers exploring the applications of graphene oxide will find immense value in this review. The comprehensive behavior towards the alchemy of graphene oxide will aid in better apprehension of the current approaches, scope and their limitations in utilizing this remarkable material. Moreover, to promote further research and development in this area, we deliberate on the technical challenges associated with graphene oxide and offer suggestions for several future research directions. This review serves as a valuable resource, encouraging scientific advancements and innovation in the exploration of graphene oxide's potential in various applications. To facilitate further research and development, the technical challenges are discussed, and several future research directions are also suggested in this paper.