Inflammatory-stimuli-responsive turn-on NIR fluorogenic theranostic prodrug: adjuvant delivery of diclofenac and hydrogen sulfide attenuates acute inflammatory disorders

ROS-responsive fluorogenic prodrug DCF-HS was developed for the delivery of the anti-inflammatory drug diclofenac and carbonyl sulfide (COS) with turn-on NIR fluorescence and the subsequent hydrolysis of COS to H 2 S by the enzyme carbonic anhydrase.