丘脑
帕金森病
白质
基底神经节
心脏病学
神经科学
医学
生物标志物
执行功能障碍
病理生理学
延迟(音频)
内科学
物理医学与康复
心理学
听力学
疾病
磁共振成像
中枢神经系统
认知
放射科
化学
生物化学
电气工程
神经心理学
工程类
作者
Harm J. van der Horn,Andrei A. Vakhtin,Kayla Julio,Stephanie Nitschke,Nicholas Shaff,Andrew B. Dodd,Erik B. Erhardt,J. P. Phillips,Sarah Pirio Richardson,Amanda Deligtisch,Melanie Stewart,Gerson Suarez Cedeno,Sanne K. Meles,Andrew R. Mayer,Sephira G. Ryman
标识
DOI:10.1177/0271678x241241895
摘要
A mounting body of research points to cerebrovascular dysfunction as a fundamental element in the pathophysiology of Parkinson’s disease (PD). In the current feasibility study, blood-oxygen-level-dependent (BOLD) MRI was used to measure cerebrovascular reactivity (CVR) in response to hypercapnia in 26 PD patients and 16 healthy controls (HC), and aimed to find a multivariate pattern specific to PD. Whole-brain maps of CVR amplitude (i.e., magnitude of response to CO 2 ) and latency (i.e., time to reach maximum amplitude) were computed, which were further analyzed using scaled sub-profile model principal component analysis (SSM-PCA) with leave-one-out cross-validation. A meaningful pattern based on CVR latency was identified, which was named the PD CVR pattern (PD-CVRP). This pattern was characterized by relatively increased latency in basal ganglia, sensorimotor cortex, supplementary motor area, thalamus and visual cortex, as well as decreased latency in the cerebral white matter, relative to HC. There were no significant associations with clinical measures, though sample size may have limited our ability to detect significant associations. In summary, the PD-CVRP highlights the importance of cerebrovascular dysfunction in PD, and may be a potential biomarker for future clinical research and practice.
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