Comparative investigation of neoadjuvant immunotherapy versus adjuvant immunotherapy in perioperative patients with cancer: a global-scale, cross-sectional, large-sample informatics study

医学 肿瘤科 新辅助治疗 内科学 微卫星不稳定性 免疫疗法 癌症 乳腺癌 等位基因 生物化学 化学 微卫星 基因
作者
Song-Bin Guo,Linjun Hu,Weijuan Huang,Zhen-Zhong Zhou,Hongyu Luo,Xiao‐Peng Tian
出处
期刊:International Journal of Surgery [Wolters Kluwer]
标识
DOI:10.1097/js9.0000000000001479
摘要

Background: Neoadjuvant and adjuvant immunotherapies for cancer have evolved through a series of remarkable and critical research advances; however, addressing their similarities and differences is imperative in clinical practice. Therefore, this study aimed to examine their similarities and differences from the perspective of informatics analysis. Methods: This cross-sectional study retrospectively analyzed extensive relevant studies published between 2014 and 2023 using stringent search criteria, excluding non-peer-reviewed and non-English documents. The main outcome variables are publication volume, citation volume, connection strength, occurrence frequency, relevance percentage, and development percentage. Furthermore, an integrated comparative analysis was conducted using unsupervised hierarchical clustering, spatiotemporal analysis, regression statistics, and Walktrap algorithm analysis. Results: This analysis included 1,373 relevant studies. Advancements in neoadjuvant and adjuvant immunotherapies have been promising over the last decade, with an annual growth rate of 25.18% vs. 6.52% and global collaboration (International Co-authorships) of 19.93% vs. 19.84%. Respectively, five dominant research clusters were identified through unsupervised hierarchical clustering based on machine learning, among which Cluster 4 (Balance of neoadjuvant immunotherapy efficacy and safety) and Cluster 2 (Adjuvant immunotherapy clinical trials) (Average Publication Year [APY]: 2021.70±0.70 vs. 2017.54±4.59) are emerging research populations. Burst and regression curve analyses uncovered domain pivotal research signatures, including microsatellite instability (R 2 =0.7500, P =0.0025) and biomarkers (R 2 =0.6505, P =0.0086) in neoadjuvant scenarios, and the tumor microenvironment (R 2 =0.5571, P =0.0209) in adjuvant scenarios. The Walktrap algorithm further revealed that “neoadjuvant immunotherapy, non-small cell lung cancer (NSCLC), immune checkpoint inhibitors, melanoma” and “adjuvant immunotherapy, melanoma, hepatocellular carcinoma, dendritic cells” (Relevance Percentage: 100% vs. 100%, Development Percentage: 37.5% vs. 17.1%) are extremely relevant to this field but remain underdeveloped, highlighting the need for further investigation. Conclusion: This study identified pivotal research signatures and provided substantial predictions for neoadjuvant and adjuvant cancer immunotherapies. In addition, comprehensive quantitative comparisons revealed a notable shift in focus within this field, with neoadjuvant immunotherapy taking precedence over adjuvant immunotherapy after 2020; such a qualitative finding facilitate proper decision-making for subsequent research and mitigate the wastage of healthcare resources.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
spy完成签到 ,获得积分10
1秒前
1秒前
2秒前
五十完成签到,获得积分10
4秒前
Wxxxxx完成签到 ,获得积分10
4秒前
木木完成签到,获得积分10
4秒前
5秒前
6秒前
yangjoy发布了新的文献求助10
7秒前
wanci应助老实的采蓝采纳,获得10
8秒前
威哥完成签到,获得积分10
9秒前
斯可发布了新的文献求助10
9秒前
桐桐应助lh961129采纳,获得10
10秒前
JUZI发布了新的文献求助10
11秒前
Lendar完成签到 ,获得积分10
11秒前
RuiBigHead发布了新的文献求助10
12秒前
13秒前
跳跃的洋葱完成签到 ,获得积分10
13秒前
13秒前
yangjoy完成签到,获得积分10
14秒前
pinklay完成签到 ,获得积分10
14秒前
14秒前
科研通AI5应助ttt采纳,获得10
15秒前
重要问旋完成签到,获得积分10
15秒前
16秒前
香蕉觅云应助科研通管家采纳,获得10
17秒前
17秒前
酷波er应助科研通管家采纳,获得10
17秒前
华仔应助科研通管家采纳,获得10
17秒前
wanci应助科研通管家采纳,获得30
17秒前
老阎应助科研通管家采纳,获得30
17秒前
姜莹应助科研通管家采纳,获得10
17秒前
隐形曼青应助科研通管家采纳,获得10
17秒前
顾矜应助科研通管家采纳,获得10
17秒前
共享精神应助科研通管家采纳,获得10
17秒前
大模型应助科研通管家采纳,获得10
17秒前
在水一方应助科研通管家采纳,获得10
17秒前
英姑应助科研通管家采纳,获得10
17秒前
CodeCraft应助科研通管家采纳,获得10
17秒前
17秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038619
求助须知:如何正确求助?哪些是违规求助? 3576294
关于积分的说明 11375058
捐赠科研通 3306084
什么是DOI,文献DOI怎么找? 1819374
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815066