清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Unraveling the role of low‐density lipoprotein‐related genes in lung adenocarcinoma: Insights into tumor microenvironment and clinical prognosis

生物 癌变 肿瘤微环境 腺癌 免疫系统 癌症研究 转录组 计算生物学 生物信息学 基因 癌症 遗传学 基因表达
作者
P. Zhang,Shirong Guo,Dingli Wang,Mengzhe Zhang,Bin Zhang,Zhenfa Zhang
出处
期刊:Environmental Toxicology [Wiley]
被引量:1
标识
DOI:10.1002/tox.24230
摘要

The hypothesized link between low-density lipoprotein (LDL) and oncogenesis has garnered significant interest, yet its explicit impact on lung adenocarcinoma (LUAD) remains to be elucidated. This investigation aims to demystify the function of LDL-related genes (LRGs) within LUAD, endeavoring to shed light on the complex interplay between LDL and carcinogenesis.Leveraging single-cell transcriptomics, we examined the role of LRGs within the tumor microenvironment (TME). The expression patterns of LRGs across diverse cellular phenotypes were delineated using an array of computational methodologies, including AUCell, UCell, singscore, ssGSEA, and AddModuleScore. CellChat facilitated the exploration of distinct cellular interactions within LDL_low and LDL_high groups. The findmarker utility, coupled with Pearson correlation analysis, facilitated the identification of pivotal genes correlated with LDL indices. An integrative approach to transcriptomic data analysis was adopted, utilizing a machine learning framework to devise an LDL-associated signature (LAS). This enabled the delineation of genomic disparities, pathway enrichments, immune cell dynamics, and pharmacological sensitivities between LAS stratifications.Enhanced cellular crosstalk was observed in the LDL_high group, with the CoxBoost+Ridge algorithm achieving the apex c-index for LAS formulation. Benchmarking against 144 extant LUAD models underscored the superior prognostic acuity of LAS. Elevated LAS indices were synonymous with adverse outcomes, diminished immune surveillance, and an upsurge in pathways conducive to neoplastic proliferation. Notably, a pronounced susceptibility to paclitaxel and gemcitabine was discerned within the high-LAS cohort, delineating prospective therapeutic corridors.This study elucidates the significance of LRGs within the TME and introduces an LAS for prognostication in LUAD patients. Our findings accentuate putative therapeutic targets and elucidate the clinical ramifications of LAS deployment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
17秒前
49秒前
1分钟前
欣5完成签到 ,获得积分10
2分钟前
2分钟前
欣6完成签到 ,获得积分10
2分钟前
3分钟前
一颗煤炭完成签到 ,获得积分10
3分钟前
3分钟前
3分钟前
3分钟前
Echan发布了新的文献求助10
3分钟前
3分钟前
成就发夹应助jdj采纳,获得10
3分钟前
紫熊发布了新的文献求助20
4分钟前
4分钟前
able完成签到 ,获得积分10
4分钟前
4分钟前
正直的山雁完成签到,获得积分10
4分钟前
紫熊发布了新的文献求助20
5分钟前
CipherSage应助正直的山雁采纳,获得10
5分钟前
5分钟前
5分钟前
5分钟前
Owen应助正直的山雁采纳,获得10
6分钟前
紫熊发布了新的文献求助20
6分钟前
6分钟前
研友_VZG7GZ应助捋顺爆炸头采纳,获得10
6分钟前
7分钟前
GQ完成签到,获得积分10
8分钟前
8分钟前
科研通AI2S应助科研通管家采纳,获得10
8分钟前
汉堡包应助紫熊采纳,获得10
8分钟前
9分钟前
野椒搞科研完成签到,获得积分10
9分钟前
紫熊完成签到,获得积分10
9分钟前
10分钟前
11分钟前
11分钟前
万能图书馆应助lwenjing采纳,获得10
11分钟前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Pharmacogenomics: Applications to Patient Care, Third Edition 800
Gerard de Lairesse : an artist between stage and studio 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3081574
求助须知:如何正确求助?哪些是违规求助? 2734437
关于积分的说明 7532802
捐赠科研通 2383903
什么是DOI,文献DOI怎么找? 1264099
科研通“疑难数据库(出版商)”最低求助积分说明 612563
版权声明 597578