A novel strategy for the quality control of carbonized Typhae pollen using colorimeter, liquid chromatography–mass spectrometry, and efficacy evaluation coupled with multivariate statistical analysis

偏最小二乘回归 色谱法 多元统计 山奈酚 化学 数学 槲皮素 统计 抗氧化剂 生物化学
作者
Jiaqi Li,Min Tang,Zhong Yongqi,Xiaolong Li,Ge Yuewei,Shumei Wang,Shengwang Liang,Jingru Meng,Fei Sun
出处
期刊:Biomedical Chromatography [Wiley]
标识
DOI:10.1002/bmc.5856
摘要

In this study, a novel quality control strategy was proposed, aiming to establish a multivariate specification for the processing step by exploring the correlation between colors, chemical components, and hemostatic effects of the carbonized Typhae pollen (CTP) using multivariate statistical analysis. The CTP samples were stir-fried at different durations. Afterward, the colorimeter and LC-MS techniques were applied to characterize the CTP samples, followed by the determination of bleeding time and clotting time using mice to evaluate their hemostatic effect. Then, principal component analysis, hierarchical cluster analysis, and multi-block partial least squares were used for data analysis on colors, chemical components, and their correlation with the hemostatic effect. Consequently, 13 critical quality attributes (CQAs) of CTP were identified via multivariate statistical analysis-L*, a*, b*, 3,4-dihydroxybenzoic acid, 4-hydroxybenzoic acid, 3-hydroxybenzoic acid, quercetin-3-O-glucoside, azelaic acid, kaempferol-3-O-glucoside, quercetin, naringenin, kaempferol, and isorhamnetin. The multivariate specification method involving the 13 CQAs was developed and visualized in the latent variable space of the partial least squares model, indicating that the proposed method was successfully applied to assess the quality of CTP and the degree of carbonization. Most importantly, this study offers a novel insight into the control of processing for carbonized Chinese herbal medicines.
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