Physiological 68Ga-PSMA-11 Uptake in Dural Venous Sinuses

Abstract We describe hitherto unreported physiological low-grade 68 Ga-PSMA-11 uptake in dural sinuses of patients who underwent 68 Ga-PSMA-11 PET/CT for evaluation of prostate carcinoma. A strong positive correlation was found between SUV max of tracer uptake in dural sinuses and SUV max of blood pool activity in superior vena cava. Low-grade 68 Ga-PSMA-11 uptake seen in dural sinuses is physiological and is most likely result of venous blood pool activity. Such uptake should not be interpreted as pathological. Knowledge of such physiological uptake is essential for optimal interpretation of PSMA PET/CT images and differentiating physiological versus pathological uptake.