The intestinal epithelial-macrophage-crypt stem cell axis plays a crucial role in regulating and maintaining intestinal homeostasis

地穴 细胞生物学 免疫系统 肠上皮 平衡 干细胞 生物 免疫学 肠粘膜 上皮 内科学 医学 内分泌学 遗传学
作者
Xiaohui Hu,Xinyi Yuan,Guokun Zhang,Haoyun Song,Pengfei Ji,Yanan Guo,Zihua Liu,Yixiao Tian,Rong Shen,Degui Wang
出处
期刊:Life Sciences [Elsevier]
卷期号:344: 122452-122452 被引量:4
标识
DOI:10.1016/j.lfs.2024.122452
摘要

The intestinal tract plays a vital role in both digestion and immunity, making its equilibrium crucial for overall health. This equilibrium relies on the dynamic interplay among intestinal epithelial cells, macrophages, and crypt stem cells. Intestinal epithelial cells play a pivotal role in protecting and regulating the gut. They form vital barriers, modulate immune responses, and engage in pathogen defense and cytokine secretion. Moreover, they supervise the regulation of intestinal stem cells. Macrophages, serving as immune cells, actively influence the immune response through the phagocytosis of pathogens and the release of cytokines. They also contribute to regulating intestinal stem cells. Stem cells, known for their self-renewal and differentiation abilities, play a vital role in repairing damaged intestinal epithelium and maintaining homeostasis. Although research has primarily concentrated on the connections between epithelial and stem cells, interactions with macrophages have been less explored. This review aims to fill this gap by exploring the roles of the intestinal epithelial-macrophage-crypt stem cell axis in maintaining intestinal balance. It seeks to unravel the intricate dynamics and regulatory mechanisms among these essential players. A comprehensive understanding of these cell types' functions and interactions promises insights into intestinal homeostasis regulation. Moreover, it holds potential for innovative approaches to manage conditions like radiation-induced intestinal injury, inflammatory bowel disease, and related diseases.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
stop发布了新的文献求助10
刚刚
情怀应助完美冰露采纳,获得10
1秒前
1秒前
科目三应助武雨寒采纳,获得10
2秒前
悲伤土豆丝完成签到 ,获得积分10
2秒前
共享精神应助八个冬菇采纳,获得10
3秒前
3秒前
4秒前
张泽崇发布了新的文献求助10
4秒前
6秒前
6秒前
6秒前
7秒前
LArry完成签到,获得积分10
8秒前
雪糕发布了新的文献求助10
9秒前
丘比特应助科研混子采纳,获得10
10秒前
11秒前
yyy完成签到,获得积分10
12秒前
zhanks发布了新的文献求助10
12秒前
13秒前
Candice应助宁山河采纳,获得10
13秒前
13秒前
13秒前
13秒前
14秒前
YOU完成签到,获得积分10
14秒前
Axel完成签到,获得积分10
14秒前
草莓奶昔完成签到 ,获得积分10
15秒前
Lyn应助stop采纳,获得30
16秒前
zhanks完成签到,获得积分10
17秒前
诚心的砖头完成签到,获得积分10
19秒前
武雨寒发布了新的文献求助10
19秒前
章鱼完成签到,获得积分10
20秒前
Candice应助聪明的惜芹采纳,获得10
20秒前
yin发布了新的文献求助10
20秒前
葛梦竹发布了新的文献求助10
20秒前
胡胡发布了新的文献求助10
21秒前
xFanOvO完成签到,获得积分10
21秒前
雪糕完成签到,获得积分10
22秒前
22秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Very-high-order BVD Schemes Using β-variable THINC Method 870
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
Fundamentals of Dispersed Multiphase Flows 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3254378
求助须知:如何正确求助?哪些是违规求助? 2896597
关于积分的说明 8293307
捐赠科研通 2565536
什么是DOI,文献DOI怎么找? 1393084
科研通“疑难数据库(出版商)”最低求助积分说明 652418
邀请新用户注册赠送积分活动 629946