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Physical activity can reduce the risk of blood cadmium and blood lead on stroke: Evidence from NHANES

冲程(发动机) 医学 铅(地质) 入射(几何) 人口 风险因素 贝叶斯多元线性回归 镉暴露 环境卫生 心脏病学 内科学 生理学 回归分析 化学 生物 统计 毒性 数学 几何学 工程类 古生物学 有机化学 机械工程
作者
Xiaoqi Deng,Dichuan Liu,Miao Li,Jie He,Yufan Fu
出处
期刊:Toxicology and Applied Pharmacology [Elsevier BV]
卷期号:483: 116831-116831 被引量:9
标识
DOI:10.1016/j.taap.2024.116831
摘要

The detrimental impact of heavy metals on cardiovascular well-being is a global concern, and engaging in suitable physical activity has been shown to confer cardiovascular advantage. Nevertheless, the potential of exercise to mitigate the deleterious effects of heavy metals on stroke remains uncertain. We conducted a cross-sectional survey to assess the influence of blood cadmium and blood lead on stroke occurrence, while also examining the role of physical activity. Weighted multivariate regression analysis was employed to examine the potential correlation, while subgroup and interaction analyses were used to investigate the sensitivity and robustness of the results. After controlling risk factors, it revealed a positive correlation between blood cadmium and lead levels and the occurrence of stroke. Specifically, a 50% increase in blood cadmium was associated with a 28% increase in stroke incidence, while a 50% increase in blood lead was associated with a 47% increase in stroke incidence. To estimate the non-linear relationship, we employed restricted cubic models. The results demonstrate a gradual decrease in the slope of the model curve as the intensity of physical activity increases, implying that engaging in physical activity may contribute to a reduction in the occurrence of stroke caused by blood cadmium and lead. Our findings suggest that blood cadmium and lead could be considered an autonomous risk factor for stroke within the general population of the United States. Moreover, engaging in physical activity has the potential to mitigate the potential detrimental consequences associated with exposure to heavy metals.
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