弹性蛋白
材料科学
真皮
弹性模量
复合材料
弹性纤维
模数
人体皮肤
生物医学工程
线弹性
压力(语言学)
拉伤
解剖
结构工程
有限元法
病理
医学
语言学
哲学
遗传学
生物
工程类
作者
Mengyao Zhou,P. González,Ludo van Haasterecht,Alperen Soylu,Maria Mihailovski,Paul P. M. van Zuijlen,Marie Louise Groot
标识
DOI:10.1007/s10237-023-01813-3
摘要
Abstract The intact and healthy skin forms a barrier to the outside world and protects the body from mechanical impact. The skin is a complex structure with unique mechano-elastic properties. To better direct the design of biomimetic materials and induce skin regeneration in wounds with optimal outcome, more insight is required in how the mechano-elastic properties emerge from the skin’s main constituents, collagen and elastin fibers. Here, we employed two-photon excited autofluorescence and second harmonic generation microscopy to characterize collagen and elastin fibers in 3D in 24 human dermis skin samples. Through uniaxial stretching experiments, we derive uni-directional mechanical properties from resultant stress-strain curves, including the initial Young’s modulus, elastic Young’s modulus, maximal stress, and maximal and mid-strain values. The stress-strain curves show a large variation, with an average Young’s modules in the toe and linear regions of 0.1 MPa and 21 MPa. We performed a comprehensive analysis of the correlation between the key mechanical properties with age and with microstructural parameters, e.g., fiber density, thickness, and orientation. Age was found to correlate negatively with Young’s modulus and collagen density. Moreover, real-time monitoring during uniaxial stretching allowed us to observe changes in collagen and elastin alignment. Elastin fibers aligned significantly in both the heel and linear regions, and the collagen bundles engaged and oriented mainly in the linear region. This research advances our understanding of skin biomechanics and yields input for future first principles full modeling of skin tissue.
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