活性氧
自愈水凝胶
间充质干细胞
化学
间质细胞
脂肪生成
骨愈合
细胞生物学
骨髓
生物物理学
生物化学
癌症研究
免疫学
解剖
高分子化学
生物
作者
Qin Zhang,Weikai Chen,Guangfeng Li,Zhixin Ma,Mengru Zhu,Qianmin Gao,Ke Xu,Xinru Liu,Wenyi Lu,Wencai Zhang,Yan Wu,Zhongmin Shi,Jiacan Su
出处
期刊:Small
[Wiley]
日期:2024-01-02
被引量:10
标识
DOI:10.1002/smll.202306389
摘要
Abstract In view of the increased levels of reactive oxygen species (ROS) that disturb the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), the repair of diabetic bone defects remains a great challenge. Herein, a factor‐free hydrogel is reported with ROS scavenging and responsive degradation properties for enhanced diabetic bone healing. These hydrogels contain ROS‐cleavable thioketal (TK) linkers and ultraviolet (UV)‐responsive norbornene (NB) groups conjugated with 8‐arm PEG macromers, which are formed via UV crosslinking‐mediated gelation. Upon reacting with high levels of ROS in the bone defect microenvironment, ROS‐cleavable TK linkers are destroyed, allowing the responsive degradation of hydrogels, which promotes the migration of BMSCs. Moreover, ROS levels are reduced through hydrogel‐mediated ROS scavenging to reverse BMSC differentiation from adipogenic to osteogenic phenotype. As such, a favorable microenvironment is created after simultaneous ROS scavenging and hydrogel degradation, leading to the effective repair of bone defects in diabetic mouse models, even without the addition of growth factors. Thus, this study presents a responsive hydrogel platform that regulates ROS scavenging and stromal degradation in bone engineering.
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