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Faricimab Treat-and-Extend for Diabetic Macular Edema

医学 养生 血管内皮生长因子 眼科 黄斑水肿 水肿 加药 糖尿病性黄斑水肿 血管抑制剂 临床试验 血管内皮生长因子受体 外科 糖尿病性视网膜病变 内科学 视网膜 糖尿病 贝伐单抗 化疗 内分泌学
作者
Tien Yin Wong,Zdenka Hašková,Kemal Asik,Caroline R. Baumal,Karl G. Csaky,Nicole Eter,Jane A. Ives,Glenn J. Jaffe,Jean‐François Korobelnik,Hugh Lin,Toshinori Murata,Paisan Ruamviboonsuk,Patricio G. Schlottmann,András Seres,David G. Silverman,Xiaodong Sun,Yannan Tang,John A. Wells,Young Hee Yoon,Charles C. Wykoff,Thomas M. Aaberg,Ashkan M. Abbey,Elmira Abdulaeva,Santiago Abengoechea,Prema Abraham,Thomas Ach,Serrhel G. Adams,Alfredo Adán,Sean D. Adrean,Hansjürgen Agostini,Suhail Alam,Arturo Alezzandrini,Virgil Alfaro,Daniel Aliseda,Arghavan Almony,Pedro Amat,Payam Amini,Andrew N. Antoszyk,Luís Arias,Riaz Asaria,Marcos Pereira de Ávila,Carl C. Awh,Joaquín Bafalluy,Carl W. Baker,Francesco Bandello,Mark Barakat,Karen Barraza,György Bátor,Caroline R. Baumal,Rubens Belfort,Chris Bergstrom,George Bertolucci,Thomas W. Bochow,Matthias Bolz,Emilia Borcz,Arnaldo F. Bordon,David S. Boyer,Galina Bratko,Michael H. Brent,Jamin Brown,David M. Brown,M V Budzinskaya,S. Buffet,Stuart C Burgess,Ben Burton,Miguel Busquets,Francisco Cabrera,Carlo Cagini,Jorge I. Calzada,Peter A. Campochiaro,John S. Carlson,Alessandro Castellarin,Carlos Eduardo Cava,Voraporn Chaikitmongkol,Clement Chan,Emmanuel Chang,Jonathan S. Chang,Andrew Chang,Steve Charles,Nauman Chaudhry,Caroline Chee,Judy Chen,Fred K. Chen,Shih‐Jen Chen,Richard Cheong-Leen,Allen Chiang,Mark Chittum,David R. Chow,B. Connolly,Pierre Loïc Cornut,Karl G. Csaky,Carl J. Danzig,Arup Das,Vesselin Daskalov,Carmen Desco,Amr Dessouki,John D. Dickinson,Brian Do,Michael Dollin,Pravin U. Dugel,Jaroslava Dusova,David Eichenbaum,Bora Eldem,Robert E. Engstrom,Jan Ernest,Joan Josep Escobar,Simona Degli Esposti,Nicole Eter,Naomi S. Falk,Andrej Farkaš,Leonard Feiner,Nicolas Feltgen,C. Fernández,Alvaro Fernandez Vega,Philip J. Ferrone,João Figueira,Marta S. Figueroa,Oliver Findl,Howard F. Fine,Jorge A. Fortun,Gregory M. Fox,Scott Foxman,Carsten Framme,Samantha Fraser‐Bell,Arthur D. Fu,Akira Fukutomi,Nicholas Fung,Federico Furno Sola,Roberto Gallego‐Pinazo,Renata Cunha Matheus Rodrigues Garcia,Alfredo García‐Layana,Maciej Gawęcki,Sheen George,Faruque Ghanchi,Ghassan Ghorayeb,Roger A. Goldberg,Michaella Goldstein,Nuno Gomes,Francisco Gomez Ulla,Víctor H. González,Craig M. Greven,Sunil Gupta,Miguel A. Guzmán,Martin Harris,Katja Hatz,Vivienne Hau,Vincent Hau,Ken Hayashi,Jeffrey S. Heier,Ewa Herba,Vrinda Hershberger,Patrick Higgins,Akito Hirakata,Allen C. Ho,Nancy M. Holekamp,Shigeru Honda,Jason Hsu,Allen Hu,Maria Hurcikova,Yasuhiro Ikeda,Ricky Isernhagen,Yasuki Ito,Tim Jackson,Rachael Jacoby,Afsar Jafree,Golnaz Javey,Cameron Javid,Chirag Jhaveri,Mark W. Johnson,Marek Káčerik,J Kałuzný,Daniel Kampik,Se Woong Kang,Kapil Kapoor,Levent Karabaş,Tsutomu Kawasaki,Ágnes Kerényi,Arshad M. Khanani,Rahul N. Khurana,Brian Kim,Kazuhiro Kimura,Genichiro Kishino,Shigehiko Kitano,Kendra Klein-Mascia,Gregg T. Kokame,Jean François Korobelnik,Alexey N. Kulikov,Ajay E. Kuriyan,Henry Kwong,Robert Kwun,Timothy Y. Y. Lai,Chi‐Chun Lai,Philip Laird,Laurent Lalonde,Paolo Lanzetta,Michael Larsen,Caroline Schmidt Laugesen,Daniel Lavinsky,O. Lebreton,Seong Lee,Jaime Levy,Blandína Lipková,Mimi Liu,Judy Liu,Chris P. Lohmann,Nikolas London,Katrin Lorenz,Andrew Lotery,David Lozano Rechy,Silvio Lujan,Patrick Ma,Takatoshi Maeno,Sajjad Mahmood,Fuad Makkouk,Khurram Malik,Dennis M. Marcus,Alan Margherio,Leonardo Mastropasqua,Raj K. Maturi,Frank McCabe,Martin McKibbin,Hemal Mehta,Geeta Menon,Jale Menteş,Katarzyna Michalska‐Małecka,Aneta Misheva,Yoshinori Mitamura,Paul Mitchell,Yasha S. Modi,Quresh Mohamed,Javier Montero,Jeffrey S. Moore,Virgilio Morales Cantón,Haia Morori-Katz,Т. В. Моругова,Tomoaki Murakami,Maria Muzyka−Woźniak,Marco Nardi,Jan Němčanský,Kamila Nester-Ostrowska,Júlio Vieira Neto,Charles J. Newell,Massimo Nicolò,Jared S. Nielsen,Kousuke Noda,Akira Obana,Nahoko Ogata,Hideyasu Oh,Kean T. Oh,Matthew Ohr,Piotr Oleksy,Scott R. J. Oliver,Sébastien Olivier,James M. Osher,Şehnaz Özçalışkan,Banu Öztürk,András Papp,Kyu Hyung Park,D Wilkin Parke,Maria Cristina Parravano,Sugat Patel,Sunil Patel,Ian Pearce,Joel Pearlman,Fernando M. Penha,İrfan Perente,Stephen Perkins,Grazia Pertile,Iva Petkova,Tünde Petõ,Dante J. Pieramici,Andreas Pollreisz,Pear Pongsachareonnont,N. A. Pozdeyevа,Siegfried Priglinger,Jawad Qureshi,Dorota Raczyńska,Rajesh Rajagopalan,Juan Ramirez Estudillo,Paul A. Raskauskas,Rajiv Rathod,Hessam Razavi,Carl D. Regillo,Federico Ricci,Soraya Rofagha,Dominika Romanczak,Bożena Romanowska–Dixon,Daniel F. Rosberger,Irit Rosenblatt,Brett Rosenblatt,Adam H. Ross,Paisan Ruamviboonsuk,José M. Ruiz‐Moreno,Gustavo Salomão,Sukhpal S. Sandhu,Dirk Sandner,Laura Sararols,Osamu Sawada,Ramin Schadlu,Patricio G. Schlottmann,Claudia Schuart,Berthold Seitz,András Seres,Figen Şermet,Sandeep N. Shah,Ankur Shah,Rohan Shah,Sumit Sharma,Tom Sheidow,Veeral Sheth,Akito Shimouchi,Masahiko Shimura,Bartosz L. Sikorski,Rufino Silva,Michael Singer,Lawrence J. Singerman,Rishi P. Singh,Eric H. Souied,David J. Spinak,Georg Spital,Nathan Steinle,Jeffrey H. Stern,Glenn Stoller,Robert Stoltz,Cameron Stone,Amy Stone,Eric Suan,Masahiko Sugimoto,Iichiro Sugita,Jennifer K. Sun,Xiaodong Sun,Iván J. Suñer,Lajos Szalczer,Timea Szecsko,Ali Tabassian,Ramin Tadayoni,Hitoshi Takagi,Kei Takayama,Alexandre Chater Taleb,James Talks,Gavin Siew Wei Tan,Teruyo Tanabe,Stanford Taylor,Allen B. Thach,John F. Thompson,Paul S. Tlucek,Robert Torti,Daniela Tosheva Guneva,Edit Tóth‐Molnár,Eduardo Uchiyama,Attila Vajas,Deepali Varma,Balázs Varsanyi,Petja Vassileva,Sara Vaz-Pereira,Miroslav Veith,José I. Vela,Francesco Viola,Gianni Virgili,Gábor Vogt,Henrik Vorum,Pamela Weber,Thoalf Wecke,Raymond Wee,Martin Weger,Paul Weishaar,John A. Wells,Sanjeewa Wickremasinghe,Thomas Reginald Williams,Thomas Reginald Williams,Geoff Williams,Armin Wolf,Jeremy D. Wolfe,James S. W. Wong,David T. Wong,Ian C. K. Wong,Robert Wong,Bogumił Wowra,Charles C. Wykoff,Edward Wylęgała,Chang‐Hao Yang,Tsutomu Yasukawa,Paul Yates,Gürsel Yılmaz,Glenn Yiu,Young Hee Yoon,Yoreh Barak,Shigeo Yoshida,Hyeong Gon Yu,Seung Young Yu,Tatiana Yurieva,Leandro Cabral Zacharias,Karolina Zaczek Zakrzewska,Alberto Zambrano,Barbara Zatorska,Carlos Zeolite,Jeffrey Zheutlin
出处
期刊:Ophthalmology [Elsevier]
卷期号:131 (6): 708-723 被引量:17
标识
DOI:10.1016/j.ophtha.2023.12.026
摘要

To evaluate the 2-year efficacy, durability, and safety of dual angiopoietin-2 and vascular endothelial growth factor (VEGF) A pathway inhibition with intravitreal faricimab according to a personalized treat-and-extend (T&E)-based regimen with up to every-16-week dosing in the YOSEMITE and RHINE (ClinicalTrials.gov identifiers, NCT03622580 and NCT03622593, respectively) phase 3 trials of diabetic macular edema (DME).
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