Complete blood count inflammation derived indexes as predictors of metabolic syndrome in type 2 diabetes mellitus

医学 接收机工作特性 内科学 代谢综合征 2型糖尿病 中性粒细胞与淋巴细胞比率 胃肠病学 C反应蛋白 炎症 全身炎症 糖尿病 淋巴细胞 曲线下面积 前瞻性队列研究 中性粒细胞绝对计数 2型糖尿病 血小板 免疫学 内分泌学 肥胖 中性粒细胞减少症 毒性
作者
Almir Fajkić,Rijad Jahić,Edin Begić,Amela Dervišević,Avdo Kurtović,Orhan Lepara
出处
期刊:Technology and Health Care [IOS Press]
卷期号:32 (4): 2321-2330 被引量:2
标识
DOI:10.3233/thc-231101
摘要

BACKGROUND: Metabolic syndrome (MetS) is a group of comorbidities related to regulating hyperglycemia and acute cardiovascular incidents and complications. With the increasing prevalence in individuals with type 2 diabetes mellitus (T2DM), MetS represents an increasing public health problem and clinical challenge, and early diagnosis is necessary to avoid the accelerated development of diabetic complications. OBJECTIVE: To investigate the role of Complete Blood Count-derived Inflammation Indexes (CBCIIs) in predicting MetS in T2DM individuals. METHODS: The study was designed as a two-year prospective study and included 80 T2DM individuals divided into MetS and non-MetS groups based on MetS development over two years. The sera samples were analyzed for complete blood count parameters and C-reactive protein (CRP). Based on the laboratory test results, 13 CBCIIs were calculated and analyzed. The receiver operating characteristic (ROC) curve and their corresponding areas under the curve (AUC) were used to determine prognostic accuracy. RESULTS: There were significant differences between T2DM participants with Mets and those without MetS concerning Neutrophil to Platelet Ratio (NPR) values (p< 0.001), Neutrophil to Lymphocyte and Platelet Ratio (NLPR) (p< 0.001), Platelet to Lymphocyte Ratio (PLR) (p< 0.001), Lymphocyte to C-reactive protein Ratio (LCR) (p< 0.001), C-reactive protein to Lymphocyte Ratio (CRP/Ly) (p< 0.001), Systemic immune inflammation index (SII) (< 0.001), and Aggregate Index of Systemic Inflammation (AISI) (p= 0.005). The results of ROC curve analysis have shown that the LCR (AUC of 0.907), CRP/Ly (AUC of 0.907) can serve as excellent predictors, but NPR (AUC of 0.734), NLRP (AUC of 0.755), PLR (AUC of 0.823), SII (AUC of 0.745), and AISI (AUC of 0.688) as good predictors of MetS in T2 DM individuals. CONCLUSION: This study confirms the reliability of the CBCIIs as novel, simple, low cost and valuable predictors of MetS developing in T2DM.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
研友_VZG7GZ应助明亮无颜采纳,获得10
刚刚
旺仔小馒头完成签到 ,获得积分10
刚刚
李家新29完成签到,获得积分10
1秒前
研究僧发布了新的文献求助10
1秒前
今后应助NW采纳,获得10
1秒前
吕妍完成签到,获得积分10
2秒前
2秒前
5秒前
吕妍发布了新的文献求助30
6秒前
彭于晏应助清颜采纳,获得10
7秒前
NONO完成签到 ,获得积分10
8秒前
赘婿应助义气问儿采纳,获得10
10秒前
666星爷完成签到 ,获得积分10
10秒前
11秒前
12秒前
12秒前
orixero应助生动茹妖采纳,获得20
12秒前
12秒前
佳佳佳完成签到,获得积分10
15秒前
16秒前
红枫没有微雨怜完成签到 ,获得积分10
16秒前
17秒前
CartGo发布了新的文献求助10
18秒前
Flyzhang完成签到,获得积分10
18秒前
晏子完成签到,获得积分10
18秒前
goovenph完成签到,获得积分20
19秒前
19秒前
21秒前
21秒前
晏子发布了新的文献求助10
21秒前
迅速的绿蕊完成签到,获得积分10
22秒前
23秒前
俭朴水彤发布了新的文献求助10
23秒前
真凉大魔王完成签到,获得积分10
23秒前
23秒前
生动茹妖发布了新的文献求助20
26秒前
26秒前
幸福大白发布了新的文献求助10
27秒前
幽默的惮完成签到,获得积分10
28秒前
derming发布了新的文献求助10
28秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 820
England and the Discovery of America, 1481-1620 600
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3572635
求助须知:如何正确求助?哪些是违规求助? 3142841
关于积分的说明 9449037
捐赠科研通 2844177
什么是DOI,文献DOI怎么找? 1563386
邀请新用户注册赠送积分活动 731723
科研通“疑难数据库(出版商)”最低求助积分说明 718679