生殖毒性
不育
污染物
生殖系统
毒性
环境毒理学
男性不育
生理学
生物
毒理
医学
怀孕
生态学
内科学
内分泌学
遗传学
作者
Hao Li,Xin‐Run Wang,Yifan Hu,Yong-Wei Xiong,Hua-Long Zhu,Yi‐Chao Huang,Hua Wang
标识
DOI:10.1016/j.envint.2024.108898
摘要
Humans are exposed to an ever-increasing number of environmental toxicants, some of which have gradually been identified as major risk factors for male reproductive health, even associated with male infertility. Male infertility is usually due to the reproductive system damage, which may be influenced by the exposure to contaminants such as heavy metals, plasticizers, along with genetics and lifestyle. Testicular immune microenvironment (TIM) is important in maintaining normal physiological functions of the testis, whether disturbed TIM after exposure to environmental toxicants could induce reproductive toxicity remains to be explored. Therefore, the current review aims to contribute to the further understanding of exposure and male infertility by characterizing environmental exposures and the effect on TIM. We first summarized the male reproductive toxicity phenotypes induced by common environmental pollutants. Contaminants including heavy metals and plastic additives and fine particulate matter (PM
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