间充质干细胞
骨关节炎
自愈水凝胶
医学
细胞疗法
干细胞疗法
干细胞
软骨
生物相容性
活力测定
脚手架
细胞
生物医学工程
材料科学
病理
生物
细胞生物学
解剖
遗传学
高分子化学
冶金
替代医学
作者
Xiangjiang Wang,Wentao He,Hao Huang,Jiali Han,R. Wang,Hongyi Li,Ying Long,Guiqing Wang,Xianjing Han
出处
期刊:Biomolecules
[MDPI AG]
日期:2024-07-17
卷期号:14 (7): 858-858
被引量:1
摘要
Osteoarthritis (OA), a chronic joint disease affecting over 500 million individuals globally, is characterized by the destruction of articular cartilage and joint inflammation. Conventional treatments are insufficient for repairing damaged joint tissue, necessitating novel therapeutic approaches. Mesenchymal stem cells (MSCs), with their potential for differentiation and self-renewal, hold great promise as a treatment for OA. However, challenges such as MSC viability and apoptosis in the ischemic joint environment hinder their therapeutic effectiveness. Hydrogels with biocompatibility and degradability offer a three-dimensional scaffold that support cell viability and differentiation, making them ideal for MSC delivery in OA treatment. This review discusses the pathological features of OA, the properties of MSCs, the challenges associated with MSC therapy, and methods for hydrogel preparation and functionalization. Furthermore, it highlights the advantages of hydrogel-based MSC delivery systems while providing insights into future research directions and the clinical potential of this approach.
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