致盲
角膜
干细胞
病理
医学
细胞生物学
生物
眼科
临床试验
作者
Lina Sprogyte,Mijeong Park,Lamia Nureen,Nicodemus Tedla,Alexander Richardson,Nick Di Girolamo
标识
DOI:10.1016/j.jtos.2024.08.015
摘要
Limbal stem cell deficiency (LSCD) secondary to ocular surface alkali burn is a blinding condition that features corneal conjunctivalization. Mechanistic insights into its pathophysiology are lacking. Here, we developed a mouse model that recapitulates human disease to comprehensively delineate the clinicopathological features of a conjunctivalized cornea.
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