The Association Between Vitamin B12 Deficiency and Diabetic Foot Ulcer in Type 2 Diabetic Patients in Qassim Province, Saudi Arabia: A Case-Control Study

医学 维生素B12 糖尿病足 糖尿病足溃疡 内科学 2型糖尿病 胃肠病学 糖尿病 传统医学 内分泌学
作者
Dalal M Alruqayi,Jolan S Alsaud,Jood M Alsogaihi,Wateen Alsawyan,Latifah Y Almutlaq,Aishah Alsuhaibani,Ahmed Onayzan Alshammari,Habeebah Alghadouni,Mariam S. Alharbi
出处
期刊:Cureus [Cureus, Inc.]
标识
DOI:10.7759/cureus.68598
摘要

Background Diabetic foot ulcer (DFU) is a major complication of diabetes with many identified risk factors. These include poor control of diabetes, cardiovascular disease, smoking, and end-stage kidney disease. This study aims to shed light on the micronutrient status of diabetic patients and its effect on DFU, particularly, the association between vitamin B12 deficiency and DFU. Methodology This retrospective case-control study included adults in Buraydah who were at least 18 years old and had type 2 diabetes mellitus. Data were obtained from the electronic files of the patients who visited the diabetes center from January 2018 to August 2023 and were analyzed using SPSS version 27.0.1 (IBM Corp., Armonk, NY, USA). Results The research involved 221 participants, with 114 controls (individuals with diabetes but no DFU), and 107 cases (individuals with diabetes affected by DFU). Vitamin B12 levels varied, with 79.2% falling within the normal range of 187-883 pg/mL. The average age of cases (58.5 years, SD = 11.3) was notably higher than that of controls (54.1 years, SD = 14.1). Glycated hemoglobin levels were significantly higher in cases (8.7, SD = 2.0) compared to controls (7.6, SD = 2.2) (p < 0.001). Regarding physical activity, cases showed a significantly higher percentage of inactivity (62.1%) compared to controls (39.1%) (p = 0.046). Neuropathy exhibited a significant association with ulcer development, with 59.1% of cases having neuropathy compared to 23.5% of controls (p < 0.001). Furthermore, complications such as dry foot and fissures (60.0% vs. 6.3%), Charcot joint (36.8% vs. 12.2%), and foot trauma (40.9% vs. 3.9%) were significantly more prevalent in cases compared to controls (p < 0.001 for all). Conclusions The significant associations observed with advanced age, uncontrolled diabetes, longer diabetes duration, neuropathy, and specific foot complications underscore the multifactorial nature of ulcer development. The normal levels of vitamin B12 in most patients reflect no positive impact of normalized vitamin B12 levels on DFU. However, further observational studies with multiple vitamin B12 readings over a longer period are needed to establish its association with DFU development.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
lcx发布了新的文献求助10
刚刚
Lucas应助任同学采纳,获得10
1秒前
幸福大白发布了新的文献求助10
1秒前
felix完成签到,获得积分10
1秒前
2秒前
dlm完成签到,获得积分10
2秒前
2秒前
許能完成签到,获得积分10
4秒前
柴柴完成签到,获得积分10
4秒前
科研顺利完成签到,获得积分10
4秒前
彭于晏应助Starfly407采纳,获得10
4秒前
qss8807完成签到,获得积分10
5秒前
54zxy完成签到,获得积分10
5秒前
5秒前
goblue完成签到,获得积分10
5秒前
好事成双完成签到,获得积分10
5秒前
min17完成签到,获得积分10
6秒前
莉莉完成签到,获得积分10
7秒前
超然度陈完成签到,获得积分10
7秒前
ZMH完成签到,获得积分10
7秒前
兔子完成签到,获得积分10
7秒前
糖果完成签到,获得积分10
7秒前
快乐的秋翠完成签到,获得积分10
8秒前
任同学完成签到,获得积分20
8秒前
CHENXIN532发布了新的文献求助10
8秒前
091完成签到 ,获得积分10
9秒前
轻松的悟空完成签到 ,获得积分10
9秒前
桂花酒酿完成签到,获得积分10
9秒前
9秒前
三七完成签到,获得积分10
10秒前
11秒前
11秒前
hh完成签到,获得积分10
11秒前
mmm完成签到 ,获得积分10
11秒前
Galaxy完成签到,获得积分10
11秒前
小胡完成签到,获得积分10
12秒前
12秒前
美少叔叔完成签到 ,获得积分10
14秒前
phy发布了新的文献求助10
14秒前
李小狼不浪完成签到,获得积分10
14秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 850
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3249053
求助须知:如何正确求助?哪些是违规求助? 2892387
关于积分的说明 8271490
捐赠科研通 2560723
什么是DOI,文献DOI怎么找? 1389228
科研通“疑难数据库(出版商)”最低求助积分说明 651029
邀请新用户注册赠送积分活动 627870