鹅
病毒学
生物
猪圆环病毒
圆环病毒
致病性
水禽
猪细小病毒
病毒
微生物学
古生物学
生态学
栖息地
作者
Yudong Zhu,Qiong Wu,Min Wei,Dalin He,Bingrong Wu,Manyun Mao,Wentao Tang,Juntai Li,C.L. Wang,Huijun Zhao,Yu-Feng Qin,Youxiang Diao,Yi Tang
标识
DOI:10.1080/03079457.2024.2383231
摘要
Duck circovirus (DuCV) is one of the most prevalent infectious viruses in the duck industry in China. Although the clinical signs vary, it often causes immunosuppression in the host and leads to secondary infection with other pathogens. Novel goose parvovirus (NGPV) mainly infects ducks and causes short beak and dwarfism syndrome (SBDS) in ducks. However, the incidence of infection in ducks has increased in recent years, and the phenomenon of mixed infection with DuCV is common, resulting in more severe clinical morbidity. However, there are no systematic study evaluating the presence of mixed infections. In order to investigate the synergistic pathogenicity of DuCV and NGPV co-infection in SPF ducks, a comparative experiment between DuCV and NGPV co-infection and mono-infection animal models was established. The results showed that the clinical signs of short beak, dwarfism and immunosuppression were more obvious in DuCV and NGPV co-infected ducks; the tissue damage of target organs was more serious; and the viral titer of organs and cloacal swabs were more significant compared with those of SPF ducks infected with only one virus. The results indicated that co-infection with DuCV and NGPV could promote viral replication and cause more severe tissue damage and immunosuppression than single virus infection. The present study reveals that the co-infection of NGPV and DuCV has a synergistic pathogenic effect from the aspect of pathogenicity, and the conclusions drawn not only clarify the direction of the subsequent research on the mechanism of co-infection of NGPV and DuCV, but also provide a scientific basis for the research on the co-infection of immunosuppressive diseases and other diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI