医学
伤口愈合
巨噬细胞极化
糖尿病足
巨噬细胞
糖尿病
炎症
组织修复
生物信息学
免疫学
体外
内分泌学
生物
生物化学
生物医学工程
作者
Xin Zhou,Yanling Guo,Chuan Xu,Jun Wang
出处
期刊:World Journal of Diabetes
[Baishideng Publishing Group Co (World Journal of Diabetes)]
日期:2024-10-16
卷期号:15 (11): 2177-2181
被引量:15
标识
DOI:10.4239/wjd.v15.i11.2177
摘要
In this editorial, we discuss the article by Wen et al published. Diabetic foot ulcers are prevalent and serious complications of diabetes, significantly impacting patients' quality of life and often leading to disability or death, thereby placing a heavy burden on society. Effective diabetic wound healing is hindered by an imbalance in macrophage polarization; many macrophages fail to transition from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype, which is crucial for tissue remodelling and repair. The wound healing process is both dynamic and complex. Healthy M1 macrophages, which have strong phagocytic abilities, are vital during the inflammatory phase of diabetic wound healing. However, the failure to transition to M2 macrophages during the proliferative phase hinders wound healing. We anticipate the development of new therapies that can repair damaged M1 macrophages during the inflammatory phase and promote M2 macrophage polarization during the proliferative phase, thereby enhancing the overall healing process.
科研通智能强力驱动
Strongly Powered by AbleSci AI