区域选择性
化学
艾地明
烯丙基重排
催化作用
烯烃
磷化氢
产量(工程)
基质(水族馆)
钴
组合化学
有机化学
药物化学
材料科学
海洋学
冶金
地质学
作者
Jiwu Zhang,Zhikun Liang,Qinglei Chong,Fanke Meng
标识
DOI:10.1002/cjoc.202400641
摘要
Comprehensive Summary Catalytic methylative coupling of internal alkynes and aldehydes/aldimines through regioselective oxidative cyclization promoted by a phosphine–Co complex is presented. Such process constitutes an unprecedented and unique approach for Co‐catalyzed generation of metallacycles that reversed inherent regiochemical biases to furnish a wide range of allylic alcohols and allylic amides bearing a tetrasubstituted alkene in up to 98% yield with high regioselectivity, representing a novel and general strategy for reversal of substrate‐controlled regioselectivity in metal‐catalyzed oxidative cyclization.
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