mTORC1型
氨基酸
间皮细胞
背景(考古学)
纤维化
细胞生物学
化学
癌症研究
信号转导
生物化学
氨基酸代谢
生物
医学
病理
PI3K/AKT/mTOR通路
古生物学
作者
Tiangang Wu,Zanzhe Yu,Junhao Dai,Jiayang Li,Fengling Ning,Xin Liu,Nan Zhu,Xuemei Zhang
标识
DOI:10.1016/j.bbrc.2024.150656
摘要
The mesothelial-mesenchymal transition (MMT) of mesothelial cells has been recognized as a critical process during progression of peritoneal fibrosis (PF). Despite its crucial role in amino acid transport and metabolism, the involvement of L-type amino acid transporter 1 (LAT1) and the potential therapeutic role of its inhibitor, JPH203, in fibrotic diseases remain unexplored. Considering the paucity of research on amino acid-mediated mTORC1 activation in PF, our study endeavors to elucidate the protective effects of JPH203 against PF and explore the involvement of amino acid-mediated mTORC1 signaling in this context.
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