恶病质
浪费的
骨骼肌
癌症恶病质
癌症
医学
炎症
癌症研究
免疫学
肌萎缩
生物信息学
生物
内科学
作者
Yoshihiro Hayashi,Yasushige Kamimura-Aoyagi,Sayuri Nishikawa,Rena Noka,Rika Iwata,A. Iwabuchi,Yasutaka Watanabe,Natsumi Matsunuma,Kanako Yuki,Hiroki Kobayashi,Yuka Harada,Hironori Harada
标识
DOI:10.1038/s41467-024-51873-x
摘要
Most patients with advanced cancer develop cachexia, a multifactorial syndrome characterized by progressive skeletal muscle wasting. Despite its catastrophic impact on survival, the critical mediators responsible for cancer cachexia development remain poorly defined. Here, we show that a distinct subset of neutrophil-like monocytes, which we term cachexia-inducible monocytes (CiMs), emerges in the advanced cancer milieu and promotes skeletal muscle loss. Unbiased transcriptome analysis reveals that interleukin 36 gamma (IL36G)-producing CD38
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