化学
色谱法
质谱法
醋酸铵
高效液相色谱法
乙腈
降级(电信)
醋酸
液相色谱-质谱法
有机化学
电信
计算机科学
作者
Vivek Dhiman,Sourabh Ahirwar,Sowmya Chaganti,S. Gananadhamu
标识
DOI:10.1134/s1061934823040081
摘要
Venetoclax (VEN), an anticancer drug, was subjected to photolytic and oxidative degradation studies. The comprehensive degradation profiling of VEN in both conditions was reported. All the degradation products (DPs) were separated on reversed phase HPLC by employing an X-Bridge C18 column with ammonium acetate (pH adjusted to 3.20 with acetic acid) and organic solvent mixture of methanol with acetonitrile in the ratio of 90 : 10 as mobile phase. The overall results showed that it underwent significant degradation upon exposure to light (acidic pH) and oxidative (H2O2 at room temperature and 2,2-azobisisobutyronitrile at 40°C) conditions. A total of fifteen new DPs were identified with high resolution mass spectrometry data generated from liquid chromatography–high resolution mass spectrometry system. This information was used for the establishment of a complete degradation pathway of VEN. Additionally, in silico properties, viz., absorption, distribution, metabolism, excretion and toxicity (ADMET), of VEN and its DPs were predicted with admetSAR software.
科研通智能强力驱动
Strongly Powered by AbleSci AI