球霰石
碳酸钙
生物矿化
钙
化学工程
材料科学
纳米颗粒
化学
纳米技术
复合材料
文石
冶金
工程类
作者
Jean Claude Munyemana,Huixia He,Caihong Fu,Yirui Fan,Xiuxia Sun,Jianxi Xiao
出处
期刊:ACS omega
[American Chemical Society]
日期:2023-08-16
卷期号:8 (34): 30879-30887
被引量:3
标识
DOI:10.1021/acsomega.3c01467
摘要
The synthesis of calcium carbonate with controlled morphology is crucial for its biomedical applications. In this study, we synthesized well-ordered porous calcium carbonate nanospheres using recombinant collagen as a biomineralization template. Porous collagen-calcium carbonate was created by incubating calcium chloride and sodium carbonate with collagen biotemplates at room temperature. Our results show that the recombinant collagen-calcium carbonate nanomaterials underwent a morphological transition from solid nanospheres to more porous nanospheres and a phase transformation from vaterite to a mixture of calcite and vaterite. This study highlights the crucial role of recombinant collagen in modulating the morphology and crystallinity of calcium carbonate nanoparticles. Importantly, the highly porous recombinant collagen-calcium carbonate hybrid nanospheres demonstrated superior loading efficacy for the model drug cefoperazone. Furthermore, the drug loading and releasing results suggest that hybrid nanospheres have the potential to be robust and biocompatible pH-responsive drug carriers. Our findings suggest that recombinant collagen's unique amino acid content and rodlike structure make it a superior template for biomineralized synthesis. This study provides a promising avenue for the production of novel organic–inorganic nanostructures, with potential applications in biomedical fields such as drug delivery.
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