[Blood eosinophils and clinical features of pneumoconiosis complicated with chronic obstructive pulmonary disease: A cross-sectional study].

Objective: To analyze the correlation between peripheral blood eosinophil (EOS) level and clinical characteristics of patients with pneumoconiosis complicated with chronic obstructive pulmonary disease (COPD) . Methods: From January 2007 to November 2020, newly diagnosed patients with pneumoconiosis complicated with COPD in Beijing Chaoyang Hospital, were retrospectively analyzed. These patients were stratified into EOS<100 cells/μl group and EOS≥100 cells/μl group, taking 100 cells/μl as the cut-off value. Demographic characteristics, clinical symptoms, lung function and laboratory indexes were compared between the two groups. Results: The median EOS count of patients with pneumoconiosis complicated with COPD was 100 (40, 180) cells/μl. 50.2% (160/319) had blood eosinophil counts ≥100 cells/μl, and 11.0% (35/319) had blood eosinophil counts ≥300 cells/μl. In comparison with EOS<100 cells/μl group, EOS≥100 cells/μl group were older (P=0.035), had higher body mass index (P=0.008), and had lower forced respiratory volume in the first second (P=0.017), had higher the ratio of residual volume to total lung volume (P=0.010), and had lower diffusing capacity of the lung for carbon monoxide (P=0.008). Arterial partial pressure of oxygen was significantly reduced in EOS≥100 cells/μl group (P=0.039). The peripheral blood EOS count was negatively correlated with forced vital capacity, forced breathing volume in the first second, carbon monoxide diffusion, peak expiratory flow, and maximum mid expiratory flow as a percentage of expected values (r(s)=-0.22, -0.18, -0.19, -0.19, -0.19, P=0.000, 0.001, 0.003, 0.008, 0.002), and positively correlated with the ratio of residual air volume to total lung volume (r(s)=0.17, P=0.002) . Conclusion: There was a correlation between blood EOS count and pulmonary function parameters, can proide reference for the diagnosis and treatment of chnoric obstuctive pulmmory disease in clinical practice.目的： 分析尘肺病合并慢性阻塞性肺疾病（简称慢阻肺）患者外周血嗜酸性粒细胞（EOS）水平与临床特征的相关性。 方法： 于2022年4月，回顾性分析2007年1月至2020年11月在首都医科大学附属北京朝阳医院首次诊断为尘肺病合并稳定期慢阻肺患者（319例）的临床资料。以外周血嗜酸性粒细胞（EOS）100个/μl为界值，将患者分为EOS<100个/μl组和EOS≥100个/μl组。比较两组患者的人口学特征、临床症状、肺功能指标、实验室指标。 结果： 尘肺病合并稳定期慢阻肺患者血EOS计数M（Q(1)，Q(3)）为100（40，180）个/μl。50.2%（160/319）的患者外周血EOS计数≥100个/μl，11.0%（35/319）的患者外周血EOS计数≥300个/μl。与EOS计数<100个/μl组比较，EOS计数≥100个/μl组患者年龄较大（χ(2)=-2.11，P=0.035），体质指数较高（χ(2)=-2.66，P=0.008），第1秒用力呼气容积下降更明显（U=-2.39，P=0.017），残气量与肺总量比值更大（U=-2.59，P=0.010），一氧化碳弥散量更低（U=-2.67，P=0.008），动脉血氧分压明显降低（U=-2.39，P=0.039）。外周血EOS计数与用力肺活量、第1秒用力呼气容积、一氧化碳弥散量、呼气峰值流量和最大呼气中期流量占预计值百分比均呈负相关（r(s)=-0.22、-0.18、-0.19、-0.19、-0.19，P=0.000、0.001、0.003、0.008、0.002），与残气量与肺总量比值呈正相关（r(s)=0.17，P=0.002）。 结论： 血EOS计数与肺功能指标存在相关性，可为临床慢阻肺诊治提供参考。.