A review of carbon nanomaterials/bacterial cellulose composites for nanomedicine applications

Carbon nanomaterials (CNMs) mainly include fullerene, carbon nanotubes, graphene, carbon quantum dots, nanodiamonds, and their derivatives. As a new type of material in the field of nanomaterials, it has outstanding physical and chemical properties, such as minor size effects, substantial specific surface area, extremely high reaction activity, biocompatibility, and chemical stability, which have attracted widespread attention in the medical community in the past decade. However, the single use of carbon nanomaterials has problems such as self-aggregation and poor water solubility. Researchers have recently combined them with bacterial cellulose to form a new intelligent composite material to improve the defects of carbon nanomaterials. This composite material has been widely synthesized and used in targeted drug delivery, biosensors, antibacterial dressings, tissue engineering scaffolds, and other nanomedicine fields. This paper mainly reviews the research progress of carbon nanomaterials based on bacterial cellulose in nanomedicine. In addition, the potential cytotoxicity of these composite materials and their components in vitro and in vivo was discussed, as well as the challenges and gaps that need to be addressed in future clinical applications.