Predictors of coronary atherosclerosis in middle-aged and older endurance athletes

医学 运动员 内科学 冠状动脉疾病 血压 心脏病学 冠状动脉粥样硬化 耐力训练 物理疗法
作者
Kristian Berge,Vincent L. Aengevaeren,Arend Mosterd,Birgitta K. Velthuis,Thijs M.H. Eijsvogels
出处
期刊:European Heart Journal [Oxford University Press]
卷期号:44 (Supplement_2)
标识
DOI:10.1093/eurheartj/ehad655.1161
摘要

Abstract Background Exercise improves cardiovascular health, but emerging evidence indicates that coronary atherosclerosis is more prevalent in middle-aged and older endurance athletes than sedentary peers. It has been shown that greater lifelong exercise volumes and exercise training at a very vigorous intensity are associated with higher coronary artery calcification scores (CACS). Nevertheless, the underlying mechanisms responsible for accelerated coronary atherosclerosis in veteran athletes are unknown and largely unexplored. Purpose To identify predictors of CACS in middle-aged and older endurance athletes. Methods Cardiac CT scans were performed on 284 middle-aged and older male athletes of the MARC-2 study to assess CACS. Participants were stratified to CACS=0, CACS: 1-100, CACS: 101-400, or CACS >400. Participant characteristics, traditional cardiovascular risk factors, biomarker concentrations, nutrition characteristics, perceived stress scores, and usage of immune-modulating and performance-enhancing drugs were compared across CACS subgroups, whereas linear regression with backward elimination was used to determine associations with ln(CACS + 1). Results Participants were 60.0 [Q1-3 56.3-66.0] years old, had a weekly training load of 25.7 [16.9-35.2] MET-h, BMI of 24.5 [22.9-26.7] kg/m2, systolic blood pressure (SBP) of 140±18 mmHg, and reported 0.3 [0.0-8.0] smoking pack years. CACS was 31 [0-132], with 29% of athletes having CACS of 0, 40% 1-100, 18% 101-400, and 13% >400. Participants with CACS >400 were older (p<0.001), had higher SBP (p=0.004), had smoked more pack years (p=0.003), and had more often a family history of cardiovascular disease (p=0.001), compared to lower CACS groups. After backward selection, our final multivariable model (R2=0.12) revealed that alcohol intake (p=0.021), smoking pack years (p=0.027), and SBP (p=0.004) had a positive relationship with CACS, while total fat intake (p=0.005) had an inverse relationship with CACS. We also found a significant interaction effect between weekly training load with alcohol consumption (p=0.017) and SBP (p=0.028), indicating that the association of alcohol and SBP with CACS was stronger for individuals performing higher exercise volumes. Conclusion Alcohol consumption, smoking history, and SBP were the strongest predictors of CACS in our cohort of middle-aged and older male endurance athletes, whereas the effect size of alcohol consumption and SBP on CACS was larger for participants with higher training loads. Our findings indicate that high exercise volumes do not eliminate the cardiovascular risk associated with an unhealthy lifestyle.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
失眠的狗发布了新的文献求助10
刚刚
哈尔婧完成签到,获得积分10
刚刚
刚刚
1秒前
Arvilzzz完成签到,获得积分10
3秒前
3秒前
Abby完成签到,获得积分10
5秒前
拼搏的松鼠完成签到,获得积分10
5秒前
6秒前
SYLH应助廿澍采纳,获得30
6秒前
木水发布了新的文献求助10
6秒前
齐映雁完成签到 ,获得积分10
7秒前
遥远发布了新的文献求助30
7秒前
9秒前
10秒前
11秒前
11秒前
xn201120发布了新的文献求助10
11秒前
12秒前
zhangmeimei发布了新的文献求助10
13秒前
搜集达人应助自然剑采纳,获得10
14秒前
超级白猫发布了新的文献求助10
14秒前
15秒前
15秒前
15秒前
樊孟完成签到,获得积分10
16秒前
16秒前
坚定的啤酒完成签到,获得积分10
16秒前
17秒前
17秒前
Vivian完成签到,获得积分10
17秒前
18秒前
21秒前
猫猫头发布了新的文献求助30
22秒前
羊羊羊发布了新的文献求助10
23秒前
超级白猫完成签到,获得积分10
23秒前
xn201120发布了新的文献求助10
24秒前
25秒前
遥远完成签到,获得积分10
25秒前
irvinzp完成签到,获得积分10
26秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976267
求助须知:如何正确求助?哪些是违规求助? 3520472
关于积分的说明 11203425
捐赠科研通 3257089
什么是DOI,文献DOI怎么找? 1798589
邀请新用户注册赠送积分活动 877785
科研通“疑难数据库(出版商)”最低求助积分说明 806523