脂锚定蛋白
ATG5型
ATG12
自噬
细胞生物学
自噬体
生物
ATG16L1
溶酶体
ATG8型
内体
膜
生物化学
酶
细胞内
细胞凋亡
作者
Dale Corkery,Yao‐Wen Wu
出处
期刊:Autophagy
[Informa]
日期:2023-10-23
卷期号:: 1-2
标识
DOI:10.1080/15548627.2023.2267414
摘要
ATG16L1 is an essential component of the Atg8-family protein conjugation machinery, providing membrane targeting for the ATG12–ATG5 conjugate. Recently, we identified an alternative E3-like complex that functions independently of ATG16L1. This complex utilizes the autophagosome-lysosome tethering factor TECPR1 for membrane targeting. TECPR1 is recruited to damaged lysosomal membranes via a direct interaction with sphingomyelin. At the damaged membrane, TECPR1 assembles into an E3-like complex with ATG12–ATG5 to regulate unconventional LC3 lipidation and promote efficient lysosomal repair.
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