生物
MDA5型
RNA沉默
RNA结合蛋白
核糖核酸
细胞生物学
病毒学
遗传学
RNA干扰
基因
作者
Tyler J. Dorrity,Hachung Chung
出处
期刊:Molecular Cell
[Elsevier]
日期:2023-11-01
卷期号:83 (21): 3760-3762
被引量:1
标识
DOI:10.1016/j.molcel.2023.10.005
摘要
In this issue, Hu and Heraud-Farlow et al.1 demonstrate that ADAR1 dsRNA editing and dsRNA binding activities are critical to repress MDA5 and PKR, respectively, and that PKR and MDA5 act in concert to induce fatality in ADAR1 KO mice.
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