重编程
巨噬细胞
表型
生物
转录组
肿瘤微环境
癌症
计算生物学
免疫学
生物信息学
癌症研究
细胞
免疫系统
基因
基因表达
遗传学
体外
作者
Ibraheem Nasir,Conor McGuinness,Christopher G. Love,Matthias Ernst,Phillip K. Darcy,Kara Britt
标识
DOI:10.1016/j.it.2023.10.007
摘要
Abstract
Macrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, phenotype, and functional plasticity of macrophages. Overlaying the wealth of current information regarding macrophage molecular subtypes and functions has also identified novel therapeutic vulnerabilities that might drive better control of tumor-associated macrophages (TAMs). Here, we discuss the functional profiling of macrophages and provide an update of novel macrophage-targeted therapies in development.
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