亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Proton Beam Therapy for Hepatocellular Carcinoma: Multicenter Prospective Registry Study in Japan

医学 肝细胞癌 内科学 前瞻性队列研究 放射治疗 多中心研究 胃肠病学 外科 随机对照试验
作者
Masashi Mizumoto,Hiroyuki Ogino,Toshiyuki Okumura,Kazuki Terashima,Masao Murakami,Takashi Ogino,Hiroyasu Tamamura,Tetsuo Akimoto,Takahiro Waki,Norio Katoh,Masayuki Araya,Tsuyoshi Onoe,M. Takagi,Hiromitsu Iwata,Haruko Numajiri,Tomoaki Okimoto,Yusuke Uchinami,Kazushi Maruo,Kei Shibuya,Hideyuki Sakurai
出处
期刊:International Journal of Radiation Oncology Biology Physics [Elsevier BV]
卷期号:118 (3): 725-733 被引量:12
标识
DOI:10.1016/j.ijrobp.2023.09.047
摘要

IntroductionA prospective multicenter registry study was started in May 2016 in Japan to evaluate the efficacy and safety of proton beam therapy (PBT) for hepatocellular carcinoma (HCC).MethodsPatients who received PBT for HCC from May 2016 to June 2018 were registered in the database of the Particle Beam Therapy Committee and Subcommittee of the Japanese Society for Radiation Oncology (JASTRO). Overall survival (OS), progression-free survival (PFS) and local recurrence were evaluated.ResultsOf the 755 registered cases, 576 with initial PBT and no duplicate cancer were evaluated. At final follow-up, 322 patients were alive and 254 had died. The median follow-up period for survivors was 39 months (0-58 months). The median OS time of the 576 patients was 48.8 months (95% CI 42.0-55.6 months) and the 1-, 2-, 3- and 4-year OS rates were 83.8% (95% CI 80.5-86.6%), 68.5% (64.5-72.2%), 58.2% (53.9-62.2%), and 50.1% (44.9-55.0%), respectively. Recurrence was observed in 332 cases, including local recurrence in 45 cases. The median PFS time was 14.7 months (95% CI 12.4-17.0 months) and the 1-, 2-, 3- and 4-year PFS rates were 55.2% (95% CI 51.0-59.2%), 37.5% (33.5-41.5%), 30.2% (26.3-34.2%), and 22.8% (18.5-27.4%), respectively. The 1-, 2-, 3- and 4-year OS rates were significantly higher for tumor size <5 vs. 5-10 cm (p<0.001) and <5 vs. ≥10 cm (p<0.001); Child-Pugh score A/B vs. C (p<0.001); and distance of the tumor from the gastrointestinal tract <1 vs. 1-2 cm (p<0.008) and <1 vs. >2 cm (p<0.001). At final follow-up, 27 patients (4.7%) had late adverse events of grade 3 or higher, with liver failure (n=7) and dermatitis (n=7) being most common.ConclusionThis multicenter prospective data registry indicated that PBT for HCC gives good therapeutic effects (3-year local control rate of 90%) with a low risk of severe late adverse events.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
8秒前
Xw完成签到,获得积分10
16秒前
科研通AI5应助迷人问兰采纳,获得10
31秒前
Hello应助LSH970829采纳,获得10
41秒前
Xw发布了新的文献求助10
44秒前
寒冷的应助核桃采纳,获得30
59秒前
wen发布了新的文献求助10
1分钟前
隐形曼青应助科研通管家采纳,获得10
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
MchemG应助科研通管家采纳,获得10
1分钟前
wen完成签到,获得积分10
1分钟前
1分钟前
1分钟前
1分钟前
yar应助wen采纳,获得10
1分钟前
核桃发布了新的文献求助30
1分钟前
迷人问兰发布了新的文献求助10
1分钟前
1分钟前
牛牛完成签到 ,获得积分10
2分钟前
时间煮雨我煮鱼完成签到,获得积分10
2分钟前
Plum22发布了新的文献求助10
3分钟前
BiuBiu怪完成签到,获得积分10
3分钟前
bkagyin应助陈苗采纳,获得10
4分钟前
核桃发布了新的文献求助10
4分钟前
Plum22完成签到 ,获得积分10
5分钟前
自由觅松发布了新的文献求助20
5分钟前
5分钟前
核桃发布了新的文献求助10
5分钟前
深情安青应助科研通管家采纳,获得10
5分钟前
科研通AI2S应助科研通管家采纳,获得10
5分钟前
阳阳阳发布了新的文献求助10
5分钟前
阳阳阳完成签到,获得积分10
5分钟前
5分钟前
5分钟前
CATH完成签到 ,获得积分10
5分钟前
5分钟前
zhanghao发布了新的文献求助10
5分钟前
Hillson完成签到,获得积分10
6分钟前
糯糯完成签到 ,获得积分10
6分钟前
6分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990084
求助须知:如何正确求助?哪些是违规求助? 3532108
关于积分的说明 11256447
捐赠科研通 3271016
什么是DOI,文献DOI怎么找? 1805171
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228