亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Transmitted drug resistance and subtype patterns of viruses from reported new HIV diagnoses in Germany, 2017–2020

抗药性 整合酶 逆转录酶 病毒学 医学微生物学 抗性突变 整合酶抑制剂 医学 传输(电信) 人类免疫缺陷病毒(HIV) 生物 内科学 抗逆转录病毒疗法 病毒载量 聚合酶链反应 遗传学 基因 工程类 电气工程
作者
Uwe Fiebig,Britta Altmann,Andrea Hauser,Uwe Koppe,Kirsten Hanke,Barbara Gunsenheimer‐Bartmeyer,Viviane Bremer,Axel Baumgarten,Norbert Bannert
出处
期刊:BMC Infectious Diseases [Springer Nature]
卷期号:23 (1) 被引量:1
标识
DOI:10.1186/s12879-023-08649-3
摘要

Abstract Background The transmission of resistant HIV variants jeopardizes the effective use of antiretrovirals for therapy and prophylaxis. Molecular surveillance of new HIV diagnoses with a focus on prevalence and type of resistance associated mutations and the subtype of circulating viruses is mandatory. Method From 2017 to 2020, 11,527 new HIV diagnoses were reported in Germany to the Robert Koch Institute (RKI). Protease (PR) and reverse-transcriptase (RT) sequences were obtained from 4559 (39.6%) cases, and PR, RT and integrase (IN) sequences were obtained from 3097 (26.9%) cases. The sequences were analyzed with data from the national HIV reports. Results Among all cases in the analysis, the proportion of primary resistance was 4.3% for nucleoside reverse-transcriptase inhibitors (NRTIs), 9.2% for non-NRTI (NNRTIs), 3.3% for protease inhibitors (PIs) and 1.4% for integrase inhibitors (INIs). Dual-class resistance was highest for NRTIs/NNRTIs with 1.2%. There was no trend in the proportion of viruses resistant to drug classes. Most individual key mutations associated with relevant resistance had a prevalence below 1% including K65R (0.1%) and M184V (0.6%). A notable exception was K103NS, with a prevalence of 2.9% and a significant increase (p Trend =0.024) during 2017–2020. In this period, diagnoses of infections with HIV-1 subtype B were the most common at 58.7%, but its prevalence was declining (p Trend =0.049) while the frequency of minority subtypes (each < 1%) increased (p Trend =0.007). Subtype B was highest (75.6%) in men who have sex with men (MSM) and lowest in reported heterosexual transmissions (HETs, 22.6%). Conclusion The percentage of primary resistance was high but at a stable level. A genotypic determination of resistance is therefore still required before the start of therapy. The subtype diversity of circulating HIV-1 is increasing.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
ddddyooo完成签到 ,获得积分10
1秒前
77关闭了77文献求助
1秒前
红红酱发布了新的文献求助10
13秒前
通科研完成签到 ,获得积分10
13秒前
熊一只发布了新的文献求助10
21秒前
wwwww发布了新的文献求助10
39秒前
红红酱发布了新的文献求助10
42秒前
TXZ06完成签到,获得积分10
50秒前
耶格尔完成签到 ,获得积分10
53秒前
小艾完成签到 ,获得积分10
1分钟前
小冯完成签到 ,获得积分10
1分钟前
纳米完成签到,获得积分10
1分钟前
栗悟饭完成签到,获得积分10
1分钟前
1分钟前
张必雨发布了新的文献求助10
1分钟前
丸子鱼完成签到 ,获得积分10
1分钟前
研友_X84KrZ完成签到 ,获得积分10
1分钟前
酷波er应助科研通管家采纳,获得10
1分钟前
CipherSage应助科研通管家采纳,获得10
1分钟前
Owen应助科研通管家采纳,获得10
1分钟前
JacekYu完成签到 ,获得积分10
1分钟前
鱼块完成签到 ,获得积分10
1分钟前
冰糖葫芦娃完成签到 ,获得积分10
2分钟前
77完成签到,获得积分10
2分钟前
77发布了新的文献求助10
2分钟前
33完成签到 ,获得积分10
2分钟前
ddddddd完成签到 ,获得积分10
2分钟前
爆米花应助十三月的过客采纳,获得10
2分钟前
无花果应助卡皮巴拉采纳,获得10
2分钟前
2分钟前
2分钟前
2分钟前
jarrykim完成签到,获得积分10
3分钟前
华仔应助科研通管家采纳,获得10
3分钟前
嗯哼应助科研通管家采纳,获得20
3分钟前
嗯哼应助科研通管家采纳,获得20
3分钟前
caca完成签到,获得积分10
3分钟前
3分钟前
红红酱发布了新的文献求助10
4分钟前
明理丹烟完成签到 ,获得积分10
4分钟前
高分求助中
中国国际图书贸易总公司40周年纪念文集 大事记1949-1987 2000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
草地生态学 880
Threaded Harmony: A Sustainable Approach to Fashion 799
Basic Modern Theory of Linear Complex Analytic 𝑞-Difference Equations 510
中国有机(类)肥料 500
Queer Politics in Times of New Authoritarianisms: Popular Culture in South Asia 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3059518
求助须知:如何正确求助?哪些是违规求助? 2715495
关于积分的说明 7445252
捐赠科研通 2361019
什么是DOI,文献DOI怎么找? 1251143
科研通“疑难数据库(出版商)”最低求助积分说明 607698
版权声明 596448