放射免疫疗法
头颈部鳞状细胞癌
免疫疗法
医学
放射治疗
头颈部癌
癌症研究
肿瘤微环境
肿瘤科
免疫系统
癌症
临床试验
内科学
免疫学
抗体
单克隆抗体
作者
Xin Zhou,Xiaoshen Wang
出处
期刊:Biomedicines
[MDPI AG]
日期:2022-08-17
卷期号:10 (8): 1990-1990
被引量:6
标识
DOI:10.3390/biomedicines10081990
摘要
HPV-associated head and neck squamous cell carcinoma (HNSCC) is a cancer entity with unique biological and clinical characteristics that requires more personalized treatment strategies. As the backbone of conventional therapeutics, radiation is now harnessed to synergize with immunotherapy in multiple malignancies. Accumulating preclinical and clinical data have suggested the potential of radioimmunotherapy in eliciting local and systemic anti-tumor response via direct killing of tumor cells and immunogenic cell death. However, this effect remains uncertain in HPV-associated HNSCC. Owing to its intrinsic radiosensitivity and distinct tumor microenvironment, HPV-associated HNSCC may represent a good candidate for radioimmunotherapy. In this review, we provide a detailed illustration of the biology, the genomic features, and immune landscapes of HPV-associated HNSCC that support the synergism between radiation and immune agents. The interaction between radiotherapy and immunotherapy is described. We also highlight the present evidence as well as ongoing trials using different combination strategies in the recurrent/metastatic or definitive settings. In addition, we have summarized the challenges and outlook for future trial design, with special emphasis on radiotherapy optimization and novel therapeutic options to incorporate.
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