Sleep stability in isolated rapid eye movement sleep behavior disorder, Parkinson's disease, and dementia with Lewy bodies

非快速眼动睡眠 快速眼动睡眠行为障碍 路易氏体型失智症 多导睡眠图 快速眼动睡眠 心理学 共核细胞病 帕金森病 慢波睡眠 听力学 眼球运动 睡眠(系统调用) 睡眠阶段 唤醒 痴呆 神经科学 医学 内科学 脑电图 疾病 α-突触核蛋白 计算机科学 操作系统
作者
Paulo Bugalho,Marta Magriço
出处
期刊:Acta Neurologica Scandinavica [Wiley]
卷期号:146 (5): 545-552 被引量:2
标识
DOI:10.1111/ane.13677
摘要

Non-REM sleep symptoms remain poorly understood in alpha-synucleinopathies.The aims of the study were to compare sleep stability and transitions, arousals, and sleep cycle structure between isolated rapid eye movement (REM) sleep behavior disorder (iRBD), Parkinson's disease (PD), and dementia with Lewy Bodies (DLB).Sleep transition and stability measures were assessed in one-night video-polysomnography records. Transition measures were the number of shifts between Wake and REM, Wake and NREM, and REM and NREM. Stability measures were the number of passages within the same sleep stage. We assessed arousals, the number/duration of sleep cycles (defined as a sequence of any NREM stage to REM), and the duration of N3 and REM sleep in each cycle. These variables were compared between two sets of groups (PD vs. DLB vs. iRBD and RDB+ vs. RBD-).We assessed 54 PD, 24 DLB, and 21 iRBD patients (54 RBD+, 22 RBD-). There were no significant differences regarding sleep stability measures. Arousal indices in N1 and N2 stages were significantly higher in PD compared with iRBD. 24% of the sample did not have any sleep cycle. PD had significantly fewer cycles than iRBD. Differences became non-significant when adjusting for medication. There was no effect of group or time of night in REM or N3 duration. There were no significant differences between RBD+ and RBD-.There were no significant differences in stability/transition measures. Arousals and disturbance in sleep cycling were higher in PD, but the difference was no longer significant after adjusting for medication.Different alpha-synucleinopathies have a similar degree of non-REM sleep instability, but medication could worsen symptoms in PD.
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