Abstract The increasing complexity of supply chains is putting pressure on businesses to find new ways to optimize efficiency and cut costs. One area that has seen a lot of recent development is machine learning (ML) and artificial intelligence (AI) to help manage supply chains. This paper employs machine learning (ML) and artificial intelligence (AI) algorithms to predict fraud in the supply chain. Supply chain data for this project was retrieved from real-world business transactions. The findings show that ML and AI classifiers did an excellent job predicting supply chain fraud. In particular, the AI model was the highest predictor across all performance measures. These results suggest that computational intelligence can be a powerful tool for detecting and preventing supply chain fraud. ML and AI classifiers can analyze vast amounts of data and identify patterns that may evade manual detection. The findings presented in this paper can be used to optimize supply chain management (SCM) and make predictions of fraudulent transactions before they occur. While ML and AI classifiers are still in the early stages of development, they have the potential to revolutionize SCM. Future research should explore how these techniques can be refined and applied to other domains.