非典型纤维黄瘤
比较基因组杂交
生物
组织学
肉瘤
病理
未分化多形性肉瘤
遗传学
免疫组织化学
软组织肉瘤
染色体
基因
医学
免疫学
作者
Daniela Mihic‐Probst,Jianming Zhao,Parvin Saremaslani,Angela Baer,C. Oehlschlegel,Bruno E. Paredes,Paul Komminoth,Philipp U. Heitz
出处
期刊:PubMed
日期:2004-03-16
卷期号:24 (1): 19-26
被引量:35
摘要
Atypical fibroxanthoma (AFX) and undifferentiated high grade pleomorphic sarcoma (UpS) are histologically very similar, if not identical. However, they differ significantly in clinical outcome.We used comparative genomic hybridization (CGH) to screen 24 AFX and 12 UpS for genomic alterations.DNA copy number changes were observed in 20/24 AFX and in all UpS. The most frequent alterations occurring with comparable frequency in both tumors were deletions on chromosomes 9p and 13q. We also detected statistically significant differences of genetic alterations between the two tumors concerning deletions on 1q, 3p, 5q, 11p, 11q, gains on 7q, 12q and high level gains on 5p and 11q.Despite their very similar histology, AFX and UpS show clear differences in their genetic alterations. This might contribute to the different biological behavior of the two tumors. On the other hand the similarities in genetic alterations on chromosomes 9p and 13q might suggest a common pathogenetic pathway.
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