Conventional and Power Spectrum Analysis of the Effects of Zolpidem on Sleep EEG in Patients with Chronic Primary Insomnia

In agreement with previous findings obtained in patients with chronic primary insomnia, zolpidem significantly improved sleep induction and maintenance. Moreover, zolpidem increased power density in the 0.25-1.0 Hz band during short-term and intermediate-term treatment. Nevertheless, other frequency bands in the delta range showed a relative decrease which was not statistically significant.