干细胞
癌变
生物
体细胞
细胞生物学
癌症干细胞
视网膜母细胞瘤
细胞周期
视网膜母细胞瘤蛋白
衰老
癌症研究
细胞
癌症
再生医学
癌基因
遗传学
基因
作者
Edgar Grinstein,Csaba Mahotka
出处
期刊:PubMed
日期:2009-01-01
卷期号:4 (3): 141-6
被引量:28
摘要
Divisions of somatic stem cells are required for the maintenance and regeneration of normal tissues, while divisions of cancerous stem cells likely underlie the existence of certain malignant diseases. Studies of recent years suggest that molecular mechanisms governing stem cell self-renewal can be subverted in tumorigenesis to maintain cancerous growth. This is exemplified by the proto-oncogene BMI-1 that is involved in the maintenance of somatic stem cells and in carcinogenesis within the same tissues. BMI-1 interferes with the central cellular tumor suppressor pathways linked to retinoblastoma protein (Rb) and p53. These signaling pathways control the cell cycle, cell differentiation, cellular senescence and cell death. While the roles of the pathways associated with Rb and p53 in cancer are broadly established, further elucidation thereof in stem cells might have implications in cancer research, stem cell biology and regenerative medicine.
科研通智能强力驱动
Strongly Powered by AbleSci AI