Contemporary knee designs differ considerably in the conformity that exists between the articulating surfaces of the femoral and tibial components. The thickness of the polyethylene components also varies from design to design. Conformity and thickness affect the stresses associated with surface damage and the subsequent generation of harmful polyethylene debris. In this study, the stresses and strains caused by contact were calculated for 8 contemporary knee prostheses. Finite element analysis using large-strain theory was used to determine the stresses and strains for the minimum available polyethylene thickness and for the knee in flexion. The greatest differences among designs was for the von Mises strain, which reached its maximum beneath the surface. The differences in stresses were less notable because of the nonlinear material behavior of the polyethylene. This study also confirmed the advantages of designs that have more conforming articulating surfaces and thicker polyethylene components.