哮喘
嗜酸性粒细胞
医学
痰
嗜酸性粒细胞颗粒蛋白
嗜酸性粒细胞增多症
嗜酸性阳离子蛋白
免疫学
主要碱性蛋白
支气管高反应性
呼吸系统
呼吸道疾病
内科学
病理
肺
肺结核
作者
Evangelo Frigas,David A. Loegering,Graham O. Solley,George M. Farrow,Gerald J. Gleich
出处
期刊:PubMed
日期:1981-06-01
卷期号:56 (6): 345-53
被引量:117
摘要
The eosinophil granule major basic protein (MBP) is toxic to parasites and mammalian cells. Because eosinophilia is characteristic of asthma, we tested the effect of MBP on bronchi and assayed sputa for this protein. We found that MBP damaged bronchial epithelium in vitro and produced changes that mimicked those in asthma. Radioimmunoassay of sputa from 100 consecutive patients with respiratory diseases revealed MBP levels above 0.1 mug/ml in 13 patients, and 11 of these had asthma. In 15 patient hospitalized for asthma, MBP levels of sputum were markedly elevated. Treatment with bronchodilators and glucocorticoids caused an increase peak expiratory flow rate, a reduction in blood eosinophils, and a decrease in the serum and sputum levels of MBP. The results indicate that eosinophil granule constituents are released into the bronchi in asthma and that measurement of sputum MBP may be useful in identifying asthma. The possibility that the eosinophil damages bronchial epithelium in asthma is discussed.
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