CPP-ACP complex as a new adjunctive agent for remineralisation: a review

In addition to regular professional oral hygiene visits and the application of appropriate preventive medications, successful preventive strategies involve oral health promotion, patient education and patient compliance. The Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) complex has been shown to remineralise tooth surfaces in situ when delivered in oral care products. This complex has a unique ability to deliver bio-available calcium and phosphate when they are needed most. The effectiveness of casein derivatives, specifically CCP-ACP, in caries prevention and lesion reversal has been supported by many controlled clinical studies. This review summarises the research on Casein phosphopeptide-amorphous calcium phosphate complex and provides information related to its benefit in dentistry. Further research is required to provide a scientifically supported recommendation for other clinical applications.