自身免疫性胃炎
自身免疫
医学
自身免疫性甲状腺炎
甲状腺炎
免疫学
1型糖尿病
自身免疫性疾病
点头
甲状腺
免疫系统
糖尿病
内科学
内分泌学
抗体
作者
Wai-Kwan Lam-Tse,Manou R. Batstra,Bobby P. C. Koeleman,George S. Eisenbarth,Mu G J Bruining,Henk‐Jan Aanstoot,Hemmo A. Drexhage
出处
期刊:PubMed
日期:2003-09-01
卷期号:1 (1): 22-37
被引量:35
摘要
Type 1 diabetes mellitus (DM1), autoimmune thyroid disease (ATD) and autoimmune gastritis often occur together forming the so-called autoimmune polyendocrine syndrome (APS) type 3. Thyroid autoimmunity is evident in up to one third and gastric autoimmunity in up to a quarter of patients with DM1. Also relatives of DM1 patients, particularly mothers, have higher frequencies of these autoimmune conditions. Vice versa, gastric autoimmunity is present in one third of ATD patients and islet autoimmunity in one out ten. The BB-DP rat, the NOD mouse, the OS chicken and the neonatal thymectomy mouse model are animal models of APS type 3. In these models the autoimmune destruction of the various target tissues has been shown to be a multi-step process in which several genetic polymorphisms need to converge to induce both local anomalies in the target gland and anomalies in the immune system. With regard to environmental factors, excess iodine is well known to elicit/aggravate thyroid autoimmunity in these animal models. Screening DM1 patients and their relatives (particularly females) for thyroid autoimmunity is recommended. If positive, excess iodine should be avoided and thyroxin treatment considered. Whether autoimmune thyroiditis and autoimmune gastritis patients should be screened for islet Ab is not clarified.
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