Rheological properties of injectable biomaterials

Abstract: This chapter covers a basic introduction to rheology similar to that present in many introductory bioengineering texts. Additional attention is paid to examples of the use of rheology to characterize different types of in situ gelling systems currently being researched for medical applications. The discussion focuses on the differences between materials based on types and kinetics, and data that can be obtained from rheological measurements relevant to the development of procedures for the delivery of in situ gelling materials. Some tips are provided for overcoming common experimental difficulties that may arise during use of a rheometer to characterize materials that exhibit shrinkage or evaporation. Finally, the chapter closes with a discussion of future directions in in situ gelling materials, and the effects that rheology has in shaping those directions.